Division of Cardiology, Department of Internal Medicne, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Calcitonin Secretion Disorder
- Sponsor
- Tongji Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- POAF lasting longer than 30 seconds during the first week after cardiac surgery
- Last Updated
- 4 years ago
Overview
Brief Summary
Post-operative atrial fibrillation (POAF) is one of the common complicaiton following cardiac surgery, occurring in approximately 20%-40% patients. Although POAF is associated with longer hospital stays, most POAF is short lived and resolves in the 2-4 days afer cardiac surgery.
However, a recent meta-analysis showed significant increases in 1,5, and 10 year mortality in POAF patients (odds ratio:1.60, 2.60, 1.51;95% confidence intervals: 1.52 to 1.68, 2.00 to 3.38, 1.43 to 1.60;P <0.0001), the combined adjusted risk of death (16 studies, n =84,295) was also significantly increased in patients with POAF (hazard ratio: 1.25;95% confidence interval: 1.2-1.3;P < 0.0001).
These data highlight the need to understand better the underlying mechanism of POAF. A latest research in Nature reported levels of circulating calcitonin (CT), which is the main risk factor for atrial fibrillation (AF). Global disruption of CT receptor signalling in mice causes atrial fibrosis and increases susceptibility to AF.
Here we will explore the relationship between CT and POAF.
Investigators
Li Ni
Division of Cardiology, Department of Internal Medicne
Tongji Hospital
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of no history of atrial fibrillation/flutter;
- •Heart rate ≥50 beats/min;
- •No history of emergency cardiac surgery in our hospital;
- •Participate voluntarily and sign the informed consent, and can accept the follow-up of more than 2 years.
Exclusion Criteria
- •Atrial fibrillation/flutter;
- •Left atrial diameter \>5.5cm;
- •Previous cardiac surgery or emergency surgery (\<12h);
- •Sick sinus node syndrome;
- •Ventricular preexcitation or preexcitation syndrome;
- •Second degree or above atrioventricular block;
- •7.Myocardial infarction occurred within 7 days;
- •Infection, sepsis, rheumatic or inflammatory diseases;
- •Abnormal liver and kidney function (three times higher than the upper limit of normal);
- •Uncontrolled hyperthyroidism, severe obstructive sleep apnea, and acute alcoholism;
Outcomes
Primary Outcomes
POAF lasting longer than 30 seconds during the first week after cardiac surgery
Time Frame: 2 years after cardiac surgery
The incidence of atrial fibrillation lasting longer than 30 seconds during the first week after cardiac surgery
Secondary Outcomes
- Levels of serum procalcitonin(2 years after cardiac surgery)
- Levels of serum hsCRP(2 years after cardiac surgery)
- Levels of serum cytokines(IL-1β，IL-2R，IL-6，IL-8，IL-10，TNF-α)(2 years after cardiac surgery)
- The hospitalization days(2 years after cardiac surgery)
- Ventricular rate of the atrial fibrillation(2 years after cardiac surgery)
- Levels of serum calcitonin(2 years after cardiac surgery)
- Atrial fibrillation burden after cardiac surgery(lidan2014@tjh.tjmu.edu.cn)