Post Operative Atril Fibrillation : The Impact of Oral Vitamin C in Reducing the Risk in Egyptian CABG Patients
Overview
- Phase
- Phase 4
- Intervention
- Vitamin C 500 MG Oral Capsule(High dose 2g daily)
- Conditions
- Post Operative Atrial Fibrillation
- Sponsor
- Helwan University
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- compare between high dose verses low dose of vitaminC
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Post operative atrial fibrillation (POAF) is one of the most common complications that takes place worldwide after coronary artery bypass surgeries (CABG). Many studies suggest using vitamin C as an additional treatment alongside standard therapies, such as statins and β-blockers, to reduce the risk of postoperative atrial fibrillation (POAF) in patients undergoing (CABG). Supplemental therapy with vitamin C may provide a more robust preventive effect against POAF compared to using statins and β-blockers due to its strong antioxidant effect. This implies that vitamin C can enhance the effectiveness of those medications used for POAF prevention by decreasing oxidative stress induced by the surgery.
There are conflicting data on whether or not vitamin C as an antioxidant has a protective effect against postoperative atrial fibrillation and has a significant role in shortening length of ICU and hospital stay . Even in those studies that show positive relationship of vitamin C in AF prevention, there is a diversity in the dosing regimen of vitamin C used among those previous studies.
To the best of our knowledge, most researches were conducted predominantly within a single geographic region, such as Iran, this raises the concerns about the potential bias and limits our ability to apply the findings to a broader global population.
Here, the investigators aimed to evaluate the effectiveness of vitamin C supplementation and to figure out which dose of vitamin C will prevent post-operative AF and decrease complications such as hospital stay, pneumonia and surgical site infection among older Egyptian adults.
Investigators
Sahar Mohamed Hesham
principle investigator
Helwan University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •preoperative history of Atrial fibrilliation
- •permanent pacemaker or significant bradycardia
- •Hyperoxaluria or history of nephrolithiasis
- •Left ventricular ejection fraction \< 40%
- •Contraindications to beta-blocker or vitamin C.
- •Patients with history of vitamin C consumption before surgery.
- •Chronic kidney disease with creatinine \>2 mg/dl.
Arms & Interventions
GROUP 1 (2g Vitamin C )
Intervention: Vitamin C 500 MG Oral Capsule(High dose 2g daily)
GROUP 2 (1g Vitamin C )
Intervention: Vitamin C 500 MG Oral Capsule(Low-dose 1g daily)
Control group
Intervention: placebo capsules
Outcomes
Primary Outcomes
compare between high dose verses low dose of vitaminC
Time Frame: through hospital stay, an average of 7 days
Quantify the effective dose of perioperative oral vitamin C on the incidence of the POAF during hospital stay following elective on-pump CABG surgery in old adult Egyptian patients.
Postoperative atrial fibrillation (POAF) incidence in patients undergoing coronary artery bypass (CABG) surgery through the administration of vitamin C supplementation compared to placebo group
Time Frame: through hospital stay , an average of 7 days
Evaluate the effectiveness of perioperative oral vitamin C in prevention for post operative AF following elective on-pump coronary artery bypass surgery in old adult Egyptian. patients during hospital stay.
Secondary Outcomes
- Lenght of hospital stay(through hospital stay, an average of 7 days)