The Impact of Oral Vitamin C in Prevention for Post Operative Atrial Fibrillation (POAF) in Coronary Artery Bypass Surgery (CABG) Patients
- Conditions
- Post Operative Atrial Fibrillation
- Interventions
- Drug: Vitamin C 500 MG Oral Capsule(Low-dose 1g daily)Drug: placebo capsulesDrug: Vitamin C 500 MG Oral Capsule(High dose 2g daily)
- Registration Number
- NCT06074367
- Lead Sponsor
- Helwan University
- Brief Summary
Post operative atrial fibrillation (POAF) is one of the most common complications that takes place worldwide after coronary artery bypass surgeries (CABG). Many studies suggest using vitamin C as an additional treatment alongside standard therapies, such as statins and β-blockers, to reduce the risk of postoperative atrial fibrillation (POAF) in patients undergoing (CABG). Supplemental therapy with vitamin C may provide a more robust preventive effect against POAF compared to using statins and β-blockers due to its strong antioxidant effect. This implies that vitamin C can enhance the effectiveness of those medications used for POAF prevention by decreasing oxidative stress induced by the surgery.
There are conflicting data on whether or not vitamin C as an antioxidant has a protective effect against postoperative atrial fibrillation and has a significant role in shortening length of ICU and hospital stay . Even in those studies that show positive relationship of vitamin C in AF prevention, there is a diversity in the dosing regimen of vitamin C used among those previous studies.
To the best of our knowledge, most researches were conducted predominantly within a single geographic region, such as Iran, this raises the concerns about the potential bias and limits our ability to apply the findings to a broader global population.
Here, the investigators aimed to evaluate the effectiveness of vitamin C supplementation and to figure out which dose of vitamin C will prevent post-operative AF and decrease complications such as hospital stay, pneumonia and surgical site infection among older Egyptian adults.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 180
Not provided
- preoperative history of Atrial fibrilliation
- permanent pacemaker or significant bradycardia
- Hyperoxaluria or history of nephrolithiasis
- Left ventricular ejection fraction < 40%
- Contraindications to beta-blocker or vitamin C.
- Patients with history of vitamin C consumption before surgery.
- Chronic kidney disease with creatinine >2 mg/dl.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description GROUP 2 (1g Vitamin C ) Vitamin C 500 MG Oral Capsule(Low-dose 1g daily) - Control group placebo capsules - GROUP 1 (2g Vitamin C ) Vitamin C 500 MG Oral Capsule(High dose 2g daily) -
- Primary Outcome Measures
Name Time Method compare between high dose verses low dose of vitaminC through hospital stay, an average of 7 days Quantify the effective dose of perioperative oral vitamin C on the incidence of the POAF during hospital stay following elective on-pump CABG surgery in old adult Egyptian patients.
Postoperative atrial fibrillation (POAF) incidence in patients undergoing coronary artery bypass (CABG) surgery through the administration of vitamin C supplementation compared to placebo group through hospital stay , an average of 7 days Evaluate the effectiveness of perioperative oral vitamin C in prevention for post operative AF following elective on-pump coronary artery bypass surgery in old adult Egyptian.
patients during hospital stay.
- Secondary Outcome Measures
Name Time Method Lenght of hospital stay through hospital stay, an average of 7 days Estimate the impact of of perioperative oral vitamin C supplementation on hospital length of stay following elective on-pump CABG surgery in old adult Egyptian patients.
Trial Locations
- Locations (1)
El Sheik Zayed Specialized Hospital
🇪🇬Giza, Egypt