The role of the noradrenaline and acetylcholine systems in uncertainty estimation and temporal attentio
- Conditions
- het onderzoek is van algemeen cognitief-psychologische aard en heeft geen betrekking op stoornissen of aandoeningen.niet van toepassing
- Registration Number
- NL-OMON39477
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 24
Adult participants between 18 and 30 years old, with no history of neurological disorder, hypotension, or glaucoma will be included in this study. All participants will be native Dutch speakers.
Exclusion criteria are: hypotension, bradycardia, cardiac arrhythmia, severe pulmonary conditions, head trauma, learning disabilities, pregnancy, alcoholism or substance abuse, glaucoma, renal failure or hepatic insufficiency, or use of (psychotropic) medication that may affect the central nervous system. Smokers will be excluded because of the effects of nicotine on the cholinergic system.
A heart rate of less than 60 beats per minute and/or a blood pressure lower than 100/60 mmHg will lead to exclusion prior to the test phase.
For safety reasons (i.e. to ensure optimal communication between participants and experimenter), only native Dutch speakers will be included as participants.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are cognitive task performance as reflected by<br /><br>reaction times and error rates, in addition to EEG measurements. The endpoints<br /><br>are the modulatory effects of clonidine and scopolamine relative to placebo on<br /><br>the main study parameters.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters are individual differences as operationalised by<br /><br>genotyped polymorphisms and participants* scores on personality questionnaires.<br /><br>The endpoints are correlations and statistical analyses with the results from<br /><br>the genetic analyses and with questionnaire scores.</p><br>