The Effects of Metabolic & Bariatric Surgery on Lipid Metabolism, Myeloid-Derived Suppressor Cells, and Cancer Cell Biology
Recruiting
- Conditions
- Obesity
- Interventions
- Procedure: Metabolic & Bariatric Surgery
- Registration Number
- NCT06059651
- Lead Sponsor
- Pennington Biomedical Research Center
- Brief Summary
This study aims to determine the relationship between lipid kinetics changes and blood immunosuppressive cells by metabolic surgery in two patient cohorts.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cohort 2 Metabolic & Bariatric Surgery Cohort #2 (between-subject) will enroll up to 10 women with a history of class III obesity who underwent Roux-en-Y metabolic and bariatric surgery as a standard of obesity care approximately one year before enrollment. Subjects in this cohort will be matched on demographic and clinical variables to those in Cohort #1. Cohort 1 Metabolic & Bariatric Surgery Cohort #1 (within-subject) will enroll up to 10 women with class III obesity who plan to undergo Roux-en-Y metabolic and bariatric surgery as a standard of obesity care. Subjects will complete study measures preoperatively and one year postoperatively.
- Primary Outcome Measures
Name Time Method Change in the number of circulating myeloid-derived suppressor cells Baseline, week 52 Change in insulin-inhibited adipose tissue lipolysis Baseline, week 52
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Pennington Biomedical Resarch Center
🇺🇸Baton Rouge, Louisiana, United States