Phase 2 Study of rTMS Application in Aphasic Patients Evaluated With fMRI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- vghtpe user
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Concise Chinese Aphasia Test
- Last Updated
- 12 years ago
Overview
Brief Summary
The substantial efficacy and the possible mechanism of repetitive transcranial magnetic stimulation (rTMS) improving language recovery remained unclear. It is hypothesized that the rTMS was associated with increased synaptic connection and neural regeneration which can be evaluated via functional neuroimage and neurofiber imaging analysis. The effect of rTMS intervention was monitored by clinical testing and neuroimaging study.
Detailed Description
2-week rTMS modulation has been proved to produce substantial clinical benefit with sham-controlled study. This trial aimed to investigate the possible mechanism and make clinical correlation.
Investigators
vghtpe user
Po-Yi Tsai, MD
Taipei Veterans General Hospital, Taiwan
Eligibility Criteria
Inclusion Criteria
- •Aphasic stroke in chronic stage (over 3 months)
Exclusion Criteria
- •No seizure history, no brain surgery history, no electronic device in brain or chest, no dementia
Outcomes
Primary Outcomes
Concise Chinese Aphasia Test
Time Frame: Before the rTMS intervention, at 2nd week, and 3rd month
Assess the linguistic skills such as conversation, expression, description, comprehension...
Secondary Outcomes
- Functional MRI(Before rTMS intervention, and at the day completing the rTMS treatment.)