Treatment of Aphasic Stroke Patients With rTMS
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Non Fluent Aphasia in Subacute Stroke
- Sponsor
- Assiut University
- Enrollment
- 29
- Primary Endpoint
- Hemispheric stroke scale (HSS)
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
Detailed Description
Thirty patients with subacute post-stroke non-fluent aphasia were randomly allocated with a ratio 2:1 to receive real (n = 20) or sham (n = 10) rTMS of the affected motor cortex. Each patient received 1000 rTMS pulses (1 Hertz at 110% of resting motor threshold) over the unaffected Broca's area and 1000 pulses (20 Hertz at 100% resting motor threshold) over affected left Broca's area for 10 consecutive days. LANGUAGE section of hemispheric stroke scale, Stroke Aphasic Depression Questionnaire Hospital Version (SADQ-H) and NIH stroke scale were assessed before, post sessions, 1 and 2 months after the last session . Motor threshold was assessed before and after the end of last session.
Investigators
Eman M. Khedr
Professor
Assiut University
Eligibility Criteria
Inclusion Criteria
- •acute hemiplegia with non-fluent aphasia, single thromboembolic non-haemorrhagic infarction documented by computerized tomography (CT) in the distribution of middle cerebral artery.
Exclusion Criteria
- •head injury or neurological disease other than stroke,
- •Unstable cardiac dysrhythmia,
- •Infection,
- •Hyperglycaemia
- •Prior administration of tranquilizer
- •Patients with no motor evoked response recorded from first dorsal interosseus (FDI) muscle of the affected hand
Outcomes
Primary Outcomes
Hemispheric stroke scale (HSS)
Time Frame: Change from Baseline in HSS at 2 months
Language assessment using hemispheric stroke scale (HSS)
Secondary Outcomes
- NIH Stroke Scale (NIHSS)(Change from Baseline in NIHSS at 2 months)