Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia
- Conditions
- Non Fluent Aphasia in Subacute Stroke
- Registration Number
- NCT01850836
- Lead Sponsor
- Assiut University
- Brief Summary
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
- Detailed Description
Thirty patients with subacute post-stroke non-fluent aphasia were randomly allocated with a ratio 2:1 to receive real (n = 20) or sham (n = 10) rTMS of the affected motor cortex. Each patient received 1000 rTMS pulses (1 Hertz at 110% of resting motor threshold) over the unaffected Broca's area and 1000 pulses (20 Hertz at 100% resting motor threshold) over affected left Broca's area for 10 consecutive days. LANGUAGE section of hemispheric stroke scale, Stroke Aphasic Depression Questionnaire Hospital Version (SADQ-H) and NIH stroke scale were assessed before, post sessions, 1 and 2 months after the last session . Motor threshold was assessed before and after the end of last session.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 29
- acute hemiplegia with non-fluent aphasia, single thromboembolic non-haemorrhagic infarction documented by computerized tomography (CT) in the distribution of middle cerebral artery.
- head injury or neurological disease other than stroke,
- Unstable cardiac dysrhythmia,
- Fever,
- Infection,
- Hyperglycaemia
- Prior administration of tranquilizer
- Patients with no motor evoked response recorded from first dorsal interosseus (FDI) muscle of the affected hand
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Hemispheric stroke scale (HSS) Change from Baseline in HSS at 2 months Language assessment using hemispheric stroke scale (HSS)
- Secondary Outcome Measures
Name Time Method NIH Stroke Scale (NIHSS) Change from Baseline in NIHSS at 2 months