Metabolome Analysis in Patients With Rheumatoid Arthritis
- Conditions
- RheumatoId Arthritis
- Registration Number
- NCT02960958
- Lead Sponsor
- The Catholic University of Korea
- Brief Summary
The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals. Then we determine if the patient's metabolic fingerprint could predict the development or flare-up of RA.
- Detailed Description
Compare metabolites between RA patients and healthy individuals.
1. Collection urine sample
2. Assessing urine metabolites by 1H NMR spectroscopy
3. Analyzing the relationships between metabolites and clinical variables
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- All patients with rheumatoid arthritis meet 2010 American College of Rheumatology/European League against Rheumatism classification criteria.
Exclusion Criteria
- Comorbid with other autoimmune diseases
- Confirmed with amyloidosis
- Chronic kidney disease (estimated GFR < 60 ml/min/1.73m2)
- Chronic liver disease
- Thyroid disease
- Pregnancy
- Solid tumor/hematologic malignancy within 5 years
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Metabolic fingerprint of rheumatoid arthritis 1 years Metabolomic analyses of urine from patients with rheumatoid arthritis, healthy controls and other autoimmune disease
- Secondary Outcome Measures
Name Time Method Correlations between specific metabolites and disease activity/severity of RA 1 year Identified metabolites and their clinical significances