A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery
- Registration Number
- NCT01980069
- Lead Sponsor
- Yonsei University
- Brief Summary
Investigators hypothesized that the surgical condition will be improved with the use of sugammadex in patients undergoing laryngeal microsurgery. Investigators will compare the effect of sugammadex and neostigmine on the surgical condition during laryngeal microsurgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- adult patients of age over 20 years
- scheduled for laryngeal microsurgery under general anesthesia
Exclusion Criteria
- anticipated difficult intubation, cervical spine disease, neuromuscular disease, acute or chronic renal failure, liver cirrhosis or liver failure
- history of allergy to nondepolarizing muscle relaxant
- history of malignant hyperthermia
- pregnant woman
- body mass index over 35 kg/m2
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Neostigmine arm Neostigmine Neostigmine arm Sugammadex arm Sugammadex Sugammadex arm
- Primary Outcome Measures
Name Time Method surgical condition up to 1 hour after the end of surgery Primary outcome is the proportion of patients who have clinically acceptable surgical condition. The surgeon will evaluate the surgical condition as a surgical rating scale during surgery (extremely poor condition, poor condition, acceptable condition, good condition, optimal condition).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Severance Hospital
🇰🇷Seoul, Seodaemun-gu, Korea, Republic of