nderstanding the metabolic time profile of fructose in a sample of healthy volunteers - a pilot study.
- Conditions
- healthy proband:in
- Registration Number
- DRKS00028599
- Lead Sponsor
- DLR, Institut für Luft- und Raumfahrtmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 12
Age 18 -45 years
- Male or female
- Healthy
- Written informed consent
- Not proficient in the German language
- Fructose intolerance
- Acute or chronic illness
- History of liver or kidney disease
- History of diabetes mellitus
- Blood glucose =100 mg/dl in fasting state or blood glucose =200 mg/dl in non-fasting
State
- BMI <18 or =25
- Any medications that affect study parameters.
- Alcohol and/or drug dependence
- Above-average caffeine consumption (ie, >4 cups of coffee/black tea per day)
- Smoker
- Pregnancy (early pregnancy test before each study day).
- Menopause
- No physical activity
- Extreme or high intensity sports
- Intense exercise within one week prior to the test day
- Illness with prolonged bed rest within 6 weeks prior to test day
- Hemophobia (no fear of 10 blood tests)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In order to develop a better understanding of fructose metabolism in humans and to serve <br>as supporting knowledge for future fructose studies in hypoxic conditions, blood concentrations of fructose, glucose, insulin, free fatty acids, and triglycerides will be measured. Indirect calorimetry serves to assess changes in substrate oxidation <br>rate following fructose loading.
- Secondary Outcome Measures
Name Time Method