Effect of sitting less on glucose regulation in people with diabetes mellitus type 2

Conditions: diabetes
diabetes mellitus type 2
10012653
10003216

Registration Number: NL-OMON40499

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 38

Inclusion Criteria

o Men and women: 40-75 years old
o Diabetes mellitus type 2, developed after the age of 40 years old
o Treatment with diet or oral blood lowering medication and a Hba1C <10%
o BMI: 25.0 - 35.0 kg/m2
o Moderate to intense physical activity (physical exercise): maximum 2.5 hours per week (during the last 3 months)
o Internet availability on a daily basis
o Signing Informed Consent

Exclusion Criteria

o Pregnancy
o Alcohol use: > 2 units per day (during the last 3 months)
o Experimental drug use (during the last 3 months)
o Use of insulin, corticosteroids, vitamin K antagonists and immunosuppresiva
o Triglycerides > 10.0 mmol/l
o Fasting glucose >= 11 mmol/l
o Heart failure NYHA 3 or higher
o COPD Gold 3 or higher
o Glomerular filtration rate (GFR) < 30 ml/min
o Known with a malignancy
o Diabetes mellitus type 1
o Claudicatio intermittens with walking distance < 500 meter
o Not able to bike for 40-60 minutes 15-20 km/h
o Based on history not able to walk for 3 hours per day and stand for 4 hours per day
o Mental or physical disability which makes physical acitivity not possible
o Participation in a clinical trial with medication use (in the last 3 months)
o Severe loss of vision
o Active foot ulcus or ulcus cruris
o Severe heart and vessel diseases

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>glucose regulation measured by continous glucose monitoring</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Fasting total cholesterol, non HDL cholesterol, HDL-cholesterol,<br /><br>LDL-cholesterol, triglycerides, apo B, apo A, en free fatty acids<br /><br>- Fasting glucose, insulin and C-peptide<br /><br>- High sensitivity CRP, interleukin 1 and 6 </p><br>