How does reducing sitting time improve glucose and lipid metabolism? A study to identify underlying mechanisms
Completed
- Conditions
- Insulin resistanceobesityoverweight
- Registration Number
- NL-OMON46730
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 14
Inclusion Criteria
Caucasian postmenopausal females. Aged 45-70 years at start of the study. Body mass index (BMI) 25 * 35 kg/m2. Stable dietary habits (no weight loss or gain >5kg in the past 3 months) Sedentary lifestyle (not more than 2.5 hours of intensive exercise per week in the past 3 months)
Exclusion Criteria
Type 2 diabetes Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other). Alcohol consumption of >2 servings per day. Smoking in the past 6 months. Failed sitless try-out day. Mental or physical disability which interferes with physical activity. Reported participation in night shift work 2 weeks prior to the start of the study and during study participation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Insulin sensitivity by implementing a 2-step hyperinsulinemic euglycemic<br /><br>clamp</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Ex vivo skeletal muscle mitochondrial respiration<br /><br>* Plasma substrate metabolism markers<br /><br>* Plasma cardiometabolic markers<br /><br>* Energy expenditure<br /><br>* Average resting blood pressure over 30 min<br /><br>* Intrahepatic lipid content</p><br>