Predictive Value of Procalcitonin for Bacteremia in the ICU

Completed

• Conditions: Sepsis; Procalcitonin

• Registration Number: NCT03497741
• Lead Sponsor: Rijnstate Hospital

Brief Summary

Association between plasma procalcitonin levels and positive blood cultures in critical illness patients in the ICU.

Detailed Description

Rationale: Association of procalcitonin levels and blood cultures in critical illness patients on the ICU.

Objective: Procalcitonin is an acute phase protein. As part of the acute phase response, procalcitonin is produced during sepsis. Previous research shows that procalcitonin is a biomarker for bloodstream infection. However, there is still little known about the value of procalcitonin in diagnostics for micro-organism underlying a sepsis in ICU patients. In modern practice, blood cultures are taken when a patient is septic to determine the responsible micro-organism. When procalcitonin is a predictive value for bacteremia in the ICU, the number of blood cultures can be reduced.

Study design: An observational cohort study intervention: for each patient in the ICU blood cultures were taken, the procalcitonin level was determined. During 6 months 150 patients will be included.

Main study parameters/endpoints: this study will examine the predictive value of procalcitonin in blood cultures on the ICU.

Study Timeline

• Study Start: 2017-10-01
• Study First Submitted: 2018-03-28
• Study First Submitted QC: 2018-04-12
• Study First Posted: 2018-04-13
• Primary Completion: 2019-01-01
• Study Completion: 2019-03-01
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-18
• Last Update Posted: 2024-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

• Patients admitted to the ICU
• Age > 18 years

Exclusion Criteria

• Hemodialysis/ Continuous Veno-Venous Hemofiltration

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The predictive value of procalcitonin in blood cultures on the ICU	6 months	This study will examine the predictive value of procalcitonin on blood cultures on the ICU. A high value of procalcitonin is a predictor for bacteremia.; The predictive value: procalcitonin. Primary outcome: bacteremia .

Trial Locations

Locations (1)

Rijnstate hospital; 🇳🇱 Arnhem, Gelderland, Netherlands