Effect of acupuncture for pulmonary rehabilitation and skeletal muscle atrophy in patients with stable COPD and its regulating mechanism

Not Applicable

• Conditions: stable-phased COPD

• Registration Number: ITMCTR1900002881
• Lead Sponsor: The First Affliated Hospital of Guangzhou Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. patients meeting the diagnostic criteria for COPD, who is in stable situation, or hospitalized patients because of acute exacerbation entering the stable phase after standard treatment;
2. patients aged 40-80 years old;
3. patients who can go to the hospital for treatment;
4. patients who have symptoms of COPD, such as cough, sputum, shortness of breath,etc;
5. patients who accept standardizedmedical treatment plan provided by respiratory physician.

Exclusion Criteria

1. Patients suffering from diabetes whose glycemic control are not satisfied;
2. patients suffering from peripheral vascular disease (thromboangiitis obliterans, arteriosclerosis obliterans, lower extremity arterial thrombosis, varicose veins, etc.);
3. patients suffering from lower limb joint diseases which affect the activities;
4. patients suffering from cerebrovascular disease sequelae limb movement disorder;
5. patients who undergoes unstable angina within one month, suffering from acute myocardial infarction within six months;
6. patients suffering from severe arrhythmia;
7. patients suffering from severe heart failure;
8. patients suffering from high blood pressure whose blood pressure control is not satisfied (systolic blood pressure> 160 mmHg and/or diastolic blood pressure > 100mmHg) and chronic liver and kidney dysfunction;
9. patients suffering from cognitive impairment and mental disorders, and other diseases that can affect movement.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
VE/VCO2;mMRC;METS;FVC;GOLD;VO2/Kg%pred;FEV1;MEF25%;6MWD;MEF50%;FEV1/FVC%;VEmax;MVV;VE/VO2;VO2/HR%;COPD assessment test;MEF75%;VE;

Secondary Outcome Measures

Name	Time	Method
muscular mTOR;serum IL-10;Regular blood test;serum IL-1;muscular MyoD;muscular IGF-1;serum TNF-alpha;Blood gas analysis;muscular MURF-1;muscular atrogin-1;muscular AKT;