AN EXPLORATORY PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF CEPHALOSPORIN AND FLUOROQUINOLONE IN ICU PATIENTS
Recruiting
- Conditions
- ICU, intensive care, TDM, therapeutic drug monitoring, beta-lactams, anitbiotics, cephalosporins, fluroquinolones, MIC, PK/PD, pharmacokinetcs, pharmacodynamics
- Registration Number
- NL-OMON21190
- Lead Sponsor
- Erasmus University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Written informed consent has been obtained from the patient or their legally authorized representative.
- Receiving intravenous antibiotic therapy of the target drugs.
Exclusion Criteria
- Consent not obtained.
- <18 years of age.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to document whether empirical antibiotic dosing regimens of these antibiotics achieve defined therapeutic target concentrations in ICU patients.: Achievement of the PK/PD targets. PK/PD indices are calculated for each individual patient.
- Secondary Outcome Measures
Name Time Method Comparison of observed PK/PD indices of the individual antibiotics with the length of ICU stay and sickness severity scores in ICU patients.