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临床试验/NCT02852109
NCT02852109
Unknown
不适用

Diffusion Tensor Imaging to Judge the Prognosis of Patients With Diffuse Axonal

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine0 个研究点目标入组 30 人开始时间: 2016年9月最近更新:

概览

阶段
不适用
入组人数
30
主要终点
Change in FA(fractional anisotropy)

概览

简要总结

The investigators will examine 15 patients who was firstly diagnosed as diffuse axonal injury and 15 patients negative for magnetic resonance examination with no trauma with DTI(diffusion tensor imaging). The investigators then determine the FA(fractional anisotropy)value and the ADC(apparent diffusion coefficient) value of relational interesting area(corpus callosum、brainstem、basal ganglia)to analyse the correlation between the FA(fractional anisotropy)value and ADC(apparent diffusion coefficient) value and GCS(Glasgow Coma Scale) and coma time,so that the investigators can quantify the damage degree of patients' white matter fiber.By using fiber tractography the investigators can have the extent of recovery of the patient of DAI(diffuse axonal injury) in real-time detection and give guidance for the clinical decision and the judgement of prognosis).

详细描述

The investigators will examine 15 patients who was firstly diagnosed as diffuse axonal injury and 15 patients negative for magnetic resonance examination with no trauma with DTI(diffusion tensor imaging). The investigators then determine the FA(fractional anisotropy)value and the ADC(apparent diffusion coefficient) value of relational interesting area(corpus callosum、brainstem、basal ganglia)to analyse the correlation between the FA(fractional anisotropy)value and ADC(apparent diffusion coefficient) value and GCS(Glasgow Coma Scale) and coma time,so that the investigators can quantify the damage degree of patients' white matter fiber.At the same time the investigators rebuild the white matter fiber tract(corpus callosum 、corticospinal tract、optic radiation) of patients using diffusion tensor tractography so that the investigators can judge intuitively the extent of damage and recovery. The investigators Trace the repair of nerve fibers after treatment and guide the further treatment.This trial can exactly determine the relationship between the FA(fractional anisotropy)value and ADC(apparent diffusion coefficient) value in relational interesting area and the extent of damage in patient of DAI(diffuse axonal injury).Meanwhile the trial confirms that the DTI(diffusion tensor imaging) can exactly judge the prognosis of DAI(diffuse axonal injury).Obviously by using fiber tractography the investigators can have the extent of recovery of the patient of DAI(diffuse axonal injury) in real-time detection and give guidance for the clinical decision and the judgement of prognosis).

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

性别
All
接受健康志愿者

入选标准

  • Has a history of trauma exactly
  • Immediate coma after injury
  • Increased intracranial pressure level do not agree with clinical illness severity
  • No significant changes of CT while with severe clinical manifestations

排除标准

  • 未提供

结局指标

主要结局

Change in FA(fractional anisotropy)

时间窗: Change from FA(fractional anisotropy) within 2 weeks

次要结局

  • Change in ADC(apparent diffusion coefficient)(Change from ADC(apparent diffusion coefficient) within 2 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Xiaoqiang Wang

Associate chief physician

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

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