Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries
- Conditions
- Cervical Spinal Cord Injury
- Registration Number
- NCT01712698
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.
- Detailed Description
Diffusion tensor imaging (DTI) parameters will correlate with severity of spinal cord injury in SCI patients as seen in rodent models. We will test whether the quantitative decrease in axial (λ║) diffusivity (a biomarker of axonal injury), will predict long-term functional outcomes for patients with a SCI.
Specific Aim: To examine patients after an acute SCI using DTI and to correlate the extent of acute decrease in λ║ with the presenting ASIA motor score and long-term functional outcome of the patient.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- 18-65 years of age
- Cervical spinal cord injury
- physically and mentally willing to comply with imaging
- lives in immediate area with no plans to relocate
- Associated moderate to severe head injury
- Active malignancy
- Previous spinal cord injury
- pregnancy
- inability to tolerate MRI scanning
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in AISA score 24 months Patients will be followed for the duration of their hospital stay with clinical follow-up out to 2 years. ASIA scores will be correlated with admission DTI findings(Axial Diffusivity).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Washington University, School of Medicine
🇺🇸Saint Louis, Missouri, United States