Breath carbon monoxide measurement in jaundiced newborns

Not Applicable

Completed

• Conditions: eonatal hyperbilirubinemia (jaundice); Pregnancy and Childbirth; Neonatal hyperbilirubinemia

• Registration Number: ISRCTN80570289
• Lead Sponsor: nited Italian Trading Corporation (PTE) LTD

Brief Summary

2020 results in https://pubmed.ncbi.nlm.nih.gov/32894848/ (added 15/02/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-20
• Study Completion: 2018-12-31
• Last Update Posted: 1 March 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Born or admitted in KK Women's and Children's Hospital
2. Gestational age of 35 weeks or more
3. Birth weight of 2000 g or more
4. Presence of jaundice and requiring phototherapy or presence of blood group incompatibility/G6PD deficiency

Exclusion Criteria

1. Maternal history of smoking
2. Neonates requiring respiratory support

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. ETCOc (Corrected end-tidal carbon monoxide) values, measured with a CoSense capnometer device. Two measurements will be taken, the first 12-24 hours after recruitment and the second 12-24 following the first measurement.<br><br> The following blood test measurements will be taken at the time of admission or later, as per the treating physician's discretion, and will be completed as per routine laboratory investigations:<br> 2. Serum bilirubin<br> 3. Blood counts<br> 4. Reticulocyte counts<br> 5. G6PD status<br> 6. Blood group of mother and baby<br> 7. Antibody titres<br> 8. Coombs test results<br><br>

Secondary Outcome Measures

Name	Time	Method
inear correlation between ETCOc values and the degree of hemolysis, as assessed using reticulocyte counts