Effects of Different Fresh Gas Flows on Carboxyhemoglobin Levels
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- COHb levels
研究概览
简要总结
Low flow anesthesia; It is an anesthesia practice in which, after absorbing at least 50% of the exhaled air and carbon dioxide (CO2) using a semi-closed rebreathing system, the unused anesthetic gases are mixed with a certain amount of fresh gas and then completely or partially returned to the patient in the next inspiration. Theoretically, when low flow anesthesia is compared to high or normal flow anesthesia; it is known to have advantages such as using less inhalation agent, preserving mucociliary activity, preventing microatelectasis, preserving the amount of moisture, and reducing temperature loss.
In studies conducted in different fresh gas flows, it has been observed that CO, which is thought to accumulate in the body by rebreathing in a closed circuit, increases as a result of the chemical interaction and dry CO2 absorbent. However, there is no evidence in these studies that low-flow anesthesia increases CO accumulation and alters hemodynamics.
In our clinic, low-flow and high-flow anesthesia technics are both being used. In this study, we aimed to evaluate the effects of high- and low-flow sevoflurane anesthesia applied with a closed system on perioperative carboxyhemoglobin (COHb) levels and hemodynamic system in pediatric cardiovascular surgery cases.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Months 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients between the ages of 2 months and 7 years undergoing elective cardiac surgery
- •American Society of Anesthesiology (ASA) score II ve III patients
排除标准
- •Patients undergoing emergency surgery
- •Patients who need mechanical ventilation or any respiratory support before the operation
- •Patients with left to right shunt
- •cyanotic patients
- •Patients younger than 2 months and older than 7 years
结局指标
主要结局
COHb levels
时间窗: at the 30th minute of the surgery, at the beginning of cardiopulmonary bypass, at the time of chest closure, at the time of intensive care unit admission
COHb values will be measured in arterial blood gas samples at different fresh gas flow levels.
次要结局
- extubation time(at the time that patient is extubated up to 24 hours)
- vasoactive inotrope score (VIS)(postoperative first hour)
- body temperature(at the 30th minute of the surgery, at the beginning of cardiopulmonary bypass, at the time of chest closure, at the time of intensive care unit admission)
- bleeding(24 hours)
研究者
Selin Saglam
Specialist
Başakşehir Çam & Sakura City Hospital