Effects of Humidity (During CPAP Treatment) on Mucociliary Clearance in Patients With Obstructive Sleep Apnea
Not Applicable
Terminated
- Conditions
- Obstructive Sleep Apnea
- Interventions
- Device: CPAP + No added humidityDevice: CPAP + Conventional humidityDevice: CPAP + ThermoSmart™ humidity
- Registration Number
- NCT00790166
- Lead Sponsor
- Fisher and Paykel Healthcare
- Brief Summary
That the level of humidification delivered to patients during CPAP treatment will alter the subjects mucociliary clearance rate and related mucus properties.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 4
Inclusion Criteria
- Moderate to severe obstructive sleep apnea - Apnea Hypopnea Index (AHI) > 15
- 75% of events during the diagnostic study must be obstructive
Exclusion Criteria
- Currently using CPAP treatment OR have used it in the past 4 weeks
- Intolerance of CPAP and/or CPAP mask in the past or during the titration night
- Mouth breather (unable to breath through mouth for the study period)
- < 18years old
- Nasal CPAP intolerance determined in the PSG-CPAP titration study
- Serious nasal issues
- Acute upper airway disease
- Smoker
- COPD
- Congestive heart failure
- Neuromuscular disease
- Stroke
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description CPAP + No added humidity CPAP + No added humidity - CPAP + Conventional humidity CPAP + Conventional humidity - CPAP + ThermoSmart™ humidity CPAP + ThermoSmart™ humidity -
- Primary Outcome Measures
Name Time Method mucociliary clearance. pre and post cpap treatment with varying levels of humidity
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Faculty of Medicine: Pulmonology: University of Sao Paulo Hospital
🇧🇷Sao Paulo, Brazil