Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

Recruiting

• Conditions: Barrett Esophagus; Eating Disorders; Anorexia Nervosa, Binge Eating/Purging Type; Esophageal Adenocarcinoma; Rumination; Vomiting
• Interventions: Device: EsoGuard

• Registration Number: NCT06532734
• Lead Sponsor: Denver Health and Hospital Authority

Brief Summary

To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors

Detailed Description

A prospective cohort study to assess the presence of BE in those with purging behaviors from their eating disorders has not been completed. There are multiple case reports describing a younger population not meeting typical screening guidelines whom developed this condition. To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors. Individuals with severe forms of eating disorders with purging and ruminating behaviors not meeting the current screening guidelines for BE will still test positive for BE.

Study Timeline

• Study First Submitted: 2024-07-29
• Study First Submitted QC: 2024-07-31
• Study First Posted: 2024-08-01
• Study Start: 2024-11-12
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-03
• Last Update Posted: 2025-02-05
• Primary Completion: 2025-11
• Study Completion: 2026-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Patients diagnosed with an eating disorder diagnosis that includes purging history
• Ages 18-65
• Purging history =>5 years
• Purging or rumination at a minimum of once daily upon admission.
• Admission to the ACUTE Center for Eating Disorders and Severe Malnutrition

Exclusion Criteria

• Any eating disorder diagnosis that does not include purging behaviors
• Ages under 18 and over 65
• Patients who otherwise meet the current ACG screening guidelines (chronic GERD and 3 or more risk factors for Barrett's mentioned in the Background)
• Received mandated care at time of enrollment
• Inability to consent to participate in the research

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AN-BP	EsoGuard	individuals with a dx of AN-BP, with a \>5-year history of purging, with a frequency of at least once a day.

Primary Outcome Measures

Name	Time	Method
Number of patients positive for BE	12 months	Individuals with severe forms of eating disorders with purging and ruminating behaviors not meeting a current screening guidelines for BE will test positive for BE

Trial Locations

Locations (2)

ACUTE Center for Eating Disorders and Severe Malnutrition; 🇺🇸 Denver, Colorado, United States

Denver Health and Hospital Authority; 🇺🇸 Denver, Colorado, United States