Barrett*s Esophagus and Adenocarcinoma STudy (EAST); The inflammatory background

Completed

• Conditions: Barrett's esophagus; intestinal metaplasia; replacement of normal esophageal mucosa by an intestinal type of mucosa; 10017969; 10017991

• Registration Number: NL-OMON37304
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 304

Inclusion Criteria

1. Upper gastrointestinal tract endoscopy for the indications gastro-esophageal reflux disease (GERD), aspecific complaints, BE or BE associated EAC. 2. Patients older then 18 years old. 3. Written informed consent.

Exclusion Criteria

1. Pregnancy 2. History of esophagectomy or gastrectomy. 3. Reflux symptoms in the absence of endoscopic RE. 4. Esophageal squamous cell carcinoma. 5. Cardiacarcinoma or EAC not associated with BE. 6. Unable to fill out the questionnaire.;* reflux symptoms in the absence of endoscopic RE
* esophageal squamous carcinoma
* cardiacarcinoma or EAC not associated with BE

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in the composition of immune cells and the expression of<br /><br>immunological factors between normal squamous epithelium, RE, BE and EAC.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>