Comparison on the effect of Dexmedetomidine and Lignocaine in the prevention of Etomidate-induced Myoclonus - A Randomized Trial

Shammy N1 个研究点分布在 1 个国家目标入组 104 人开始时间: 2021年8月7日最近更新: 2021年6月14日

试验速览

阶段: 不适用
状态: 尚未招募
发起方
入组人数: 104
试验地点: 1
主要终点: Incidence of Myoclonus

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is a randomized trial, to compare the efficacy of 0.5microg/kg of IV Dexmedetomidine and 1mg/kg of IV Lignocaine, in preventing Etomidate-induced Myoclonus, which will be conducted in the Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, in 104 patients in 18-65 age group, with ASA grade I and II. The study drug will be given over 5 minutes and 2 minutes after that the patient will be induced with 0.3mg/kg of Etomidate over 30 seconds. The primary outcome studied will be the incidence of myoclonus for the next 90 seconds.

研究设计

研究类型: Interventional
分配方式: Computer generated randomization
盲法: Participant and Investigator Blinded

入排标准

年龄范围: 18.00 Year(s) 至 65.00 Year(s)（—）
性别: All

入选标准

•ASA grade I and II Patients willing to participate.

排除标准

•Bradycardia
•Upper respiratory tract infection 2 weeks before surgery
•History of allergy to study drugs (Dexmedetomidine, Lignocaine, Etomidate)
•Diabetes Mellitus, Hypertension, Cardiovascular, Respiratory and Neurologic disease
•Adrenocortical dysfunction
•Morbid obesity
•Emergency surgery patients
•Received sedatives, analgesics or opioids within 24 hours prior to surgery
•Communication problems.

结局指标

主要结局

Incidence of Myoclonus

时间窗: 90 seconds

次要结局

未报告次要终点

研究者

发起方

Shammy N

申办方类型

Other [self]

研究点 (1)

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