Effects Of Caffeine On Cognitive Performance

Not Applicable

Completed

• Conditions: Caffeine
• Interventions: Dietary Supplement: PLACEBO; Dietary Supplement: 3 mg/kg of caffeine; Dietary Supplement: 6 mg/kg of caffeine

• Registration Number: NCT05995314
• Lead Sponsor: University of Castilla-La Mancha

Brief Summary

Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance.The aim of this research will be to determine the effects of different doses of caffeine on sport-related cognitive aspects.

Detailed Description

The investigators will require healthy, physically active young adults to complete three trials under the conditions: a) placebo, b) 3 mg/kg, or c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities will be assessed using the following test batteries: reaction time (DynavisionTM D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. In addition, side effects and the perceived sensation index will be recorded 24 h after each test.

Study Timeline

• Study Start: 2023-08-07
• Study First Submitted: 2023-08-08
• Study First Submitted QC: 2023-08-08
• Study First Posted: 2023-08-16
• Status Verified: 2023-09
• Primary Completion: 2023-09-04
• Study Completion: 2023-09-04
• Last Update Submitted: 2023-09-04
• Last Update Posted: 2023-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Physically active individuals ( >150 min/week moderate physical activity or >75 min/week vigorous physical activity)
• Individuals without serious and undiagnosed health problems.

Exclusion Criteria

• Individuals with color blindness.
• Regular caffeine consumers (>3 cups of coffee/day).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
PLACEBO	PLACEBO	placebo (0 mg/kg of body mass of caffeine). The capsule will be filled with 3 mg/kg of body mass of cellulose.
3mg/kg	3 mg/kg of caffeine	3 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).
6mg/kg	6 mg/kg of caffeine	6 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).

Primary Outcome Measures

Name	Time	Method
Anticipation	5 minutes	Visual acuity related to hand-eye coordination and anticipation will be assessed using the Bassin Anticipation Timer instrument. The best anticipation time (in seconds) of each condition (5, 10 and 15 mph) will be taken.
Sustained attention	10 minutes	The ability of maintaining the attention and inhibiting an appropriate response will be measured by "Go/No-Go Test" \[fastest, slowest, and average response time (in seconds), and successful attempts (percentage; %)\] and "Eriksen Flanker Test" \[congruent and incongruent reaction time (in seconds)\].
Reaction Time	10 minutes	Reaction time (in seconds) shall be assessed with the Dynavision™ D2 Visomotor Device using the "Reaction Time Test". In this test the fastest visual, motor and physical reaction time will be measured.
Memory	20 minutes	To study the modulation of memory storage processes, three 20-item word lists were created. Each word in the list will be presented for 5 s. This will be followed by a 100 s memory consolidation interval, after which there will be a 120 s period in which as many words as the participants can remember will be written down (First time). After 15 min, participants will perform a recall task (Second time) in which they will have to rewrite all the words they remember at that time.

Trial Locations

Locations (1)

Performance and Sport Rehabilitation Laboratory; 🇪🇸 Toledo, Spain