The effect of caffeine on cognitive performance and brain activity following a ‘real life’ workday - an fMRI title.

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

Only right handed physically and mentally healthy volunteers will be included.

1. Male;

Exclusion Criteria

The exclusion criteria are based on factors which are MRI contraindications or are known to affect neuropsychological task performance, brain activity, caffeine pharmacokinetics or the safety of caffeine consumption.
People who suffer from significant past or present physical or psychiatric illnesses (epilepsy, stroke, Parkinson’s disease, MS, brain surgery, brain trauma, electroshock therapy, kidney dialysis, renal dysfunction, treatment by a neurologist or psychiatrist, diabetes, heart disease, migraine, Ménière’s disease, hypertension, cardiac arrhythmias, heart palpitations, brain infections, chronic fatigue syndrome or burnout, impaired liver function, peptic ulcer disease),
who currently habitually consume nicotine at any time during weekdays (due to the effect of smoking on caffeine metabolism (Nehlig, 1999) or have drug or alcohol problems,
who receive medication at the moment of inclusion (in particular disulfiram, mexiletine, cimetidine, norfloxacin, enoxacin, ciprofloxacin, nonsteroidal anti-inflammatory drugs, aspirin, corticosteroids, phenylpropanolamine, monoamine oxidase inhibitors, antiarrhythmic agents and diazepam),
who have an MRI contraindication (brain surgery, pacemaker, metal objects/part in body, claustrophobia, large parts of the body tattooed)
or who are hypersensitive to caffeine, will be excluded from this study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main outcome measures are subjective fatigue and vitality ratings, neuropsychological performance (mean reaction time and accuracy) and the fMRI blood oxygen level dependent (BOLD) response during working memory and verbal learning tasks.

Secondary Outcome Measures

Name	Time	Method
Secondary outcome measures are the concentration of caffeine in saliva throughout the test sessions and blood glucose levels at the beginning of the test session.