Hypofractionated Intensity Modulated Chemoradiotherapy to Treat Locally Advanced Non-Small Cell Lung Cancer
Phase 2
- Conditions
- Stage III Non-Small Cell Lung Cancer
- Registration Number
- NCT00938418
- Lead Sponsor
- National University Hospital, Singapore
- Brief Summary
Locally advanced non-small cell lung cancer can be treated successfully with chemotherapy and radiation. However, the cure rate is low.
This study is carried out to find out whether giving radiotherapy at a higher dose over fewer treatment sessions with intensity modulated radiotherapy (IMRT) can improve the treatment outcome.
This study aims to recruit 43 patients from National University Hospital and Tan Tock Seng Hospital over a period of about 2 years.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 43
Inclusion Criteria
- Pathologically proven (either histologic or cytologic) diagnosis of Stage IIIA or IIIB non-small cell lung cancer; excluding patients with N3 disease based on supraclavicular or contralateral hilar adenopathy, or significant pleural / pericardial effusion.
Exclusion Criteria
- Patients for whom treatment is planned with a maximum dose of ≥ 66 Gy to the ipsilateral brachial plexus
- Greater than minimal, exudative, or cytologically positive pleural effusions
- ≥ 10% weight loss within the past month
- Prior invasive malignancy (with exceptions)
- Prior radiotherapy to the region of the study cancer
- Significant co-morbidities
- Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
- Known allergic reactions to components of planned chemotherapy regimen
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Overall survival 2 years
- Secondary Outcome Measures
Name Time Method Response rate, locoregional control, disease free survival, toxicity 2 years
Trial Locations
- Locations (2)
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
National University Hospital
🇸🇬Singapore, Singapore