Radiotracer study of the brains glymphatic system
- Conditions
- Health Condition 1: G319- Degenerative disease of nervous system, unspecifiedHealth Condition 2: G318- Other specified degenerative diseases of nervous system
- Registration Number
- CTRI/2023/09/057863
- Lead Sponsor
- Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Decompressive craniectomy group
Adult (18 years or older) traumatic brain injury (TBI) patients who have undergone a decompressive craniectomy at least three months back.
Decompressive craniectomy has to have the largest dimension of 12 cm or more on CT scan
The brain under the craniectomy defect should not have gross damage, volume loss, or infarcts though some porencephalic changes due to previous head trauma are expected.
Adults with Probable dementia
Objective cognitive or behavioral impairment in at least two of the following Memory, Reasoning and handling complex tasks Visuospatial abilities, Language functions, Personality, behavior, or comportment
A decline from the previous level of functioning Functional impairment
Insidious onset and gradual progression
Initial symptoms
Amnestic
Nonamnestic (language, executive)
No other neurologic, psychiatric, or general medical disorders of severity that can interfere with cognition
Exclusion criteria for both groups:
Abnormal creatinine levels for the age group. The creatinine clearance should be normal as the urinary excretion data will be affected if the kidney function is abnormal.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Find the pattern of SPECT-detected radiotracer distribution in patients with decompressive craniectomy and dementia. <br/ ><br> <br/ ><br>Timepoint: 24 hours after the injection <br/ ><br>
- Secondary Outcome Measures
Name Time Method ee if the urinary excretion data vary significantly after cranioplasty in patients with craniectomy defects. <br/ ><br> <br/ ><br>Timepoint: Three months;Get the urinary excretion data in this group of patients <br/ ><br>Timepoint: 24 hours after the injection;Is there a difference in the lymph node uptake on the craniectomy side compared to that on the normal side? <br/ ><br>Timepoint: 24 hours after the injection;Is there demonstrable lymph node uptake after spinal subarachnoid injection of the radiotracer? <br/ ><br>Timepoint: 24 hours after the injection