Comparison between low-dose and high-dose rocuronium use in general anesthesia for Cesarean sectio
- Conditions
- Pregnancy, childbirth and the puerperium
- Registration Number
- KCT0004986
- Lead Sponsor
- Pusan National University Hospital
- Brief Summary
o demographic differences were observed between the two groups. Additionally, no significant differences were found in intubation ease, time from rocuronium administration to skin incision, cord clamping, TOF ratio > 0.9, eye opening, extubation, PACU stay time, 1 min and 5 min Apgar score and venous blood gas analysis of the blood from the umbilical vein between both groups. However, the time from rocuronium administration to T3 disappearance was shorter in H group than in C group (p=0.009). The time from rocuronium administration to T1 and T2 reappearance were longer in H group than in C group (p=0.003, 0.009). The administered remifentanil dose was higher in H group (p=0.042), and the rocuronium concentrations in both maternal vein immediately before cord clamping and after the Aldrete score reached 9 and umbilical vein immediately after cord clamping were higher in H group than in C group (p=0.004, 0.002, and <0.001).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 18
Adult patients over 18 years of age who have undergone a cesarean section, ASA I and II
If the patient disagrees, a neuropsychiatric disorder, a history of medication or muscle relaxant administration that may affect pre-operative muscle relaxants, kidney failure, or liver failure
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rocuronium concentration of umbilical vein after umbilical cord clamping
- Secondary Outcome Measures
Name Time Method Time from the time the muscle relaxant was given until the tracheal intubation;Skin incision time from the time the muscle relaxant was given;Time for umbilical cord clamping from the time the muscle relaxant was given;Side effects in mother and fetus;Rocuronium concentration of maternal vein after umbilical cord clamping and PACU discharge