A study to compare two different dose-combinations of Propofol(Induction agent)and Ketamine(Induction agent)(Ketofol) as induction agent for patients undergoing surgery under general anaesthesia.
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2020/06/025990
- Lead Sponsor
- Government Mohan Kumaramangalam Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
American Society of Anaesthesiologists- Physical status 1 and 2
Patients undergoing elective surgical procedure requiring Endotracheal intubation
Exclusion Criteria
History of Cardiovascular of neurological disease
Pregnancy
Psychiatric disorders
Contraindication or allergies to propofol or ketamine
Emergency surgeries
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method BIS values at various intervals <br/ ><br>Time for loss of verbal contact <br/ ><br>Time for loss of eye lash reflexTimepoint: Eleven time points: Time 1, BIS at baseline; Time 2, Time at loss of verbal contact; Time 3, BIS at 5 seconds after loss of verbal contact; Time 4, Time at loss of eye lash reflex; Time 5, BIS at 5 seconds after loss of eyelash reflex; Time 6, BIS at 2 minutes after induction; Time 7, BIS before intubation; Time 8,BIS after intubation; Time 9, BIS at 5 minutes; Time 10, BIS at 10 minutes; Time 11, BIS at 20 minutes
- Secondary Outcome Measures
Name Time Method Systolic Blood Pressure <br/ ><br>Diastolic Blood Pressure <br/ ><br>Mean Arterial PressureTimepoint: Baseline <br/ ><br>After Induction <br/ ><br>After Intubation <br/ ><br>5 minutes <br/ ><br>10 minutes <br/ ><br>20 minutes