Comparison of two different doses of dexmedetomidine with ketamine -propofol combination in electroshock therapy
Phase 4
- Conditions
- Health Condition 1: F333- Major depressive disorder, recurrent, severe with psychotic symptomsHealth Condition 2: O- Medical and SurgicalHealth Condition 3: F54- Psychological and behavioral factors associated with disorders or diseases classified elsewhereHealth Condition 4: F203- Undifferentiated schizophrenia
- Registration Number
- CTRI/2023/09/057792
- Lead Sponsor
- Rabindranath Tagore Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA grade I and II having
major depressive disorder (suicidal patients), schizophrenia, catatonia
(in which first line treatment failed) were included who required MECT
Exclusion Criteria
•Patients with ASA PS III and above
•Patients with history of allergy to study drugs
•Pregnant females
•Patients with respiratory, cardiovascular, hepatic, cerebrovascular and renal disease
•Patients with intracranial hypertension, arterial aneurysm, cerebrovascular malformation etc.
•Patients with glaucoma
•Patients with history of seizure disorder
•Patients with pacemaker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Haemodynamic changesTimepoint: Baseline(before study drug infusion),after study drug infusion,after induction,immediately after modified electroconvulsive therapy , then check 2 minute interval upto 10min , 5 minutes interval upto 30 min,15 minutes interval upto 60 mim.
- Secondary Outcome Measures
Name Time Method 1.Seizure duration <br/ ><br>2.Recovery profile <br/ ><br>3.Patient satisfaction score <br/ ><br>4.Side effects / Complications, if any <br/ ><br> <br/ ><br>Timepoint: Upto 24 hours postoperatively