Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis: a Randomized Single-blind Trial of Muscle Training and Knee Orthosis Intervention
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 120
- 主要终点
- maximal voluntary isometric contraction (MVC)
研究概览
简要总结
This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation in patients with moderate knee osteoarthritis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 55 to 75 years.
- •2. Diagnosed with moderate knee traumatic arthritis (Kellgren-Lawrence classification II or III)(experimental group).
- •The control group must not have a diagnosis of osteoarthritis of the knee and must have normal knee joint function.
- •3. Physical Health Status: Able to perform basic movements requiring isometric knee contraction tests and electromyography recording.
- •4. Able to wear knee orthotics.
排除标准
- •1. Knee or lower extremity injury: Recent (within the past 6 months) history of severe injury, fracture, or surgery to the knee or lower extremity.
- •2. Other joint disorders: Coexisting joint disorders (such as rheumatoid arthritis or gouty arthritis).
- •3. Neuromuscular disorders: Presence of neuromuscular dysfunction, such as stroke, Parkinson's disease, or peripheral neuropathy.
- •4. Uncontrolled cardiovascular disease, hypertension, diabetes, or other medical conditions.
- •Taking medications that affect neuromuscular function.
- •5. Allergy or intolerance: Allergy to laboratory equipment (such as electromyography electrode gel) or knee brace materials.
研究组 & 干预措施
controls group
干预措施: the strengthening program (Behavioral)
Group A with the corrective knee orthosis
patients with moderate knee osteoarthritis (Kellgren-Lawrence grade II-III) who will receive a valgus-corrective knee orthosis.
干预措施: the strengthening program (Behavioral)
Group B without the corrective knee orthosis
patients with moderate knee osteoarthritis (Kellgren-Lawrence grade II-III) who will not receive a valgus-corrective knee orthosis.
干预措施: the strengthening program (Behavioral)
结局指标
主要结局
maximal voluntary isometric contraction (MVC)
时间窗: Baseline and 3 weeks
The Western Ontario and McMaster Universities Turkish (WOMAC) index
时间窗: baseline, 3 weeks
a self-administered questionnaire that assesses three aspects of a patient's health status -pain, stiffness, and physical function - in those with lower limb Osteoarthritis. WOMAC consists of 24 questions, with a total score ranging from 0 to 96 points. there are three subscales: pain (5 questions), stiffness (2 questions), and physical function (17 questions). a five-tier classification of symptomatic severity: minimal or no symptoms (≤24 score), mild (25-41 score), moderate (42-69 score), severe (70-86 score), and extreme (≥87 score).
The Knee Injury and Osteoarthritis Outcome Score (KOOS)
时间窗: Baseline and 3 weeks
a knee-specific instrument, developed to assess the patients' opinion about their knee and associated problems. Knee Injury and Osteoarthritis Outcome Score (KOOS) has five subscales: pain (9 questions), symptoms (7 questions), activities of daily living (17 questions), sport/recreation (5 questions), knee-related quality of life (4 questions). The total score of each question (0-4 points) is converted into a score of 0-100, where 100 points represents the best knee health and 0 points represents the worst.
Motor Unit Recruitment (amplitude relative to recruitment threshold)
时间窗: Baseline and 3 weeks
surface EMG decomposition
Motor Unit Recruitment (firing rate relative to recruitment threshold)
时间窗: Baseline and 3 weeks
surface EMG decomposition
次要结局
未报告次要终点
研究者
CHEN YUEH
Doctor of Medicine
Kaohsiung Veterans General Hospital.