ChiCTR1900027029尚未招募2 期
Structured frontal lobe based cognitive stimulation to older adults with depressive symptoms but without dementia or mild cognitive impairment
Direct Grant for Research 2018/20191 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2019年11月1日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- severity of depressive symptoms
研究概览
简要总结
- to test whether cognitive stimulation can improve depressive symptoms in older adults who are still cognitively relatively normal;
- to test whether the improvement in depressive symptoms can be explained by changes in cognitive performance, inflammatory response, and BDNF level
研究设计
- 研究类型
- Interventional
- 主要目的
- 随机抽样
- 盲法
- None
入排标准
- 年龄范围
- 55 至 75（—）
- 性别
- All
入选标准
- •Community-living Chinese individuals aged 55 to 75 years old with subjective cognitive decline and comorbid depressive symptoms will be recruited through elderly social centres in Hong Kong
排除标准
- •non-Chinese ethnicity; living in care homes; having history of stroke, traumatic brain injury, Parkinson’s disease, MCI, or clinical dementia; scoring Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA) ≤25 (i.e. the cutoff score for MCI in young old with high educational level); taking drugs that affect cognition (e.g. benzodiazepines, anti-dementia medication, etc.); having history of bipolar affective disorder, psychosis, or substance abuse; already attending other cognitive or psychological intervention programs; and having significant impairments in vision, hearing or communication
研究组 & 干预措施
对照组
watch health videos
试验组
computerized cognitive training
结局指标
主要结局
severity of depressive symptoms
次要结局
- Cognitive performance
- Blood inflammatory markers
研究者
研究点 (1)
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