ChiCTR1900027029
Not yet recruiting
Phase 2
Structured frontal lobe based cognitive stimulation to older adults with depressive symptoms but without dementia or mild cognitive impairment
Direct Grant for Research 2018/20191 site in 1 country60 target enrollmentStarted: November 1, 2019Last updated:
Overview
- Phase
- Phase 2
- Status
- Not yet recruiting
- Sponsor
- Direct Grant for Research 2018/2019
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- severity of depressive symptoms
Overview
Brief Summary
- to test whether cognitive stimulation can improve depressive symptoms in older adults who are still cognitively relatively normal;
- to test whether the improvement in depressive symptoms can be explained by changes in cognitive performance, inflammatory response, and BDNF level
Study Design
- Study Type
- 干预性研究
- Primary Purpose
- 随机抽样
- Masking
- None
Eligibility Criteria
- Ages
- 55 to 75 (—)
- Sex
- All
Inclusion Criteria
- •Community-living Chinese individuals aged 55 to 75 years old with subjective cognitive decline and comorbid depressive symptoms will be recruited through elderly social centres in Hong Kong
Exclusion Criteria
- •non-Chinese ethnicity; living in care homes; having history of stroke, traumatic brain injury, Parkinson’s disease, MCI, or clinical dementia; scoring Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA) ≤25 (i.e. the cutoff score for MCI in young old with high educational level); taking drugs that affect cognition (e.g. benzodiazepines, anti-dementia medication, etc.); having history of bipolar affective disorder, psychosis, or substance abuse; already attending other cognitive or psychological intervention programs; and having significant impairments in vision, hearing or communication
Arms & Interventions
对照组
watch health videos
试验组
computerized cognitive training
Outcomes
Primary Outcomes
severity of depressive symptoms
Secondary Outcomes
- Cognitive performance
- Blood inflammatory markers
Investigators
Study Sites (1)
Loading locations...
Similar Trials
Recruiting
Not Applicable
Cognitive Stimulation Therapy Group for Residential Home Residents With Dementia and Mild Cognitive ImpairmentNCT07372066City University of Hong Kong110
Unknown
Phase 1
Photo Neuro-Modulation Therapy to AdultsChiCTR1900027311n/a40
Unknown
Not Applicable
看老照片回忆疗法对老年抑郁症状患者的影响及作用机制的 fMRI 研究ChiCTR-OCC-14004510自筹30
Unknown
Not Applicable
李伟医师：该试验尚未获伦理委员会批准，请于批准后才开始征募参试者，并与我们联系上传伦理批件。 rTMS 对老年期首发抑郁症患者的治疗效果及其影响特定认知功能的生物学机制ChiCTR2000036188申康机构120
Unknown
Not Applicable
经颅直流电刺激治疗老年抑郁症的疗效研究ChiCTR2000029969拟申请国家自然科学基金100