Effects of Inosine Supplements on Markers of Bone Health

Phase 1

Completed

• Conditions: Post-menopausal bone health decline; Musculoskeletal - Osteoporosis

• Registration Number: ACTRN12617000940370
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-30
• Study Completion: 2019-09-30
• Last Update Posted: 16 February 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

a.Age >55 years
b.Post-menopausal
c.Female
d.eGFR >60ml/min
e.Serum urate <0.42mmol/L
f.Able to provide written informed consent and attend study visits

Exclusion Criteria

a.Bone mineral density T score <-2.5 at the total hip, femoral neck or lumbar spine
b.Previous fragility fracture of the hip or clinical spine fracture
c.Current or past use of bisphosphonate therapy within 12 months, or any past zoledronate use
d.Use of hormone replacement therapy within 12 months
e.History of gout
f.History of kidney stones
g.History of diabetes mellitus
h.Diuretic use
i.Urine pH less than 5.0 (risk factor for uric acid urolithiasis)
j.Current use of inosine as a nutritional supplement

Study & Design

• Study Type: Interventional
• Study Design: Not specified