Effect of oral vitamin D3 supplementation on biochemical factors in polycystic ovary syndrome
- Conditions
- polycystic ovarian syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT201201043140N3
- Lead Sponsor
- Student research committee
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 54
diagnosis of PCOS based on Rotterdam criteria (presence of two of the three following characteristics: 1. oligomemorreha /amenorrhea, 2. chemical or clinical finding of hyperandrogenism and 3. polycystic appearance of ovary); voluntary consent for participation in the study; female aged 18-40 years. Exclusion criteria: Other common causes of hyperandrogenemia and/or anovulation; hyperprolactinoma; congenital adrenal hyperplasia; Cushing syndrome, and virilizing ovarian or adrenal tumors; diabetes mellitus and heart, kidney and liver dysfunction; using vitamin D or Calcium supplement, metformin or insulin sensitizing drugs, corticosteroids, anticonvulsants during last 2 month or during the study; Smoking; alcohol abuse; breast feeding and pregnancy.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of bone biochemical factors. Timepoint: before and after intervention (60 days). Method of measurement: serum levels of alkaline phosphatase, calcium, phosphoruse.;Improvement of serum zinc and magnesium. Timepoint: before and after intervention (60 days). Method of measurement: serum levels of zinc and magnesium.
- Secondary Outcome Measures
Name Time Method Food habits. Timepoint: before and after intervention (60 days). Method of measurement: 3 days 24h dietaty racall.;Anthropometric indicator. Timepoint: before and after intervention (60 days). Method of measurement: Body weight without shoes with calibrated scale, Standing height without shoes are measuredl. BMI was calculated with this equation: W(kg) /H(m)2.