Intraoperative Ketamine Administration in Colorectal Surgery: Effect on Postoperative Clinical Outcomes
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Number of Participants With Opioid Consumption
研究概览
简要总结
The purpose of this research is to evaluate the effectiveness of ketamine as an analgesic adjuvant in decreasing the narcotic (opioids) analgesics during surgery, on pain management and on the later recovery after surgery in patients undergoing colorectal surgery.
详细描述
Adjuvant is a drug that has few or no pharmacological effects by itself, but may increase the effectiveness or strength of other drugs when given at the same time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Control
Loading and Infusion:
Saline at infusion rate calculated and adjusted for weight to match ketamine bolus-infusion rate
干预措施: Ketamine high-dose (Drug)
Control
Loading and Infusion:
Saline at infusion rate calculated and adjusted for weight to match ketamine bolus-infusion rate
干预措施: Ketamine low-dose (Drug)
Ketamine low-dose
Loading: 0.5 mg/Kg Infusion: 5 mcg/kg/min
干预措施: Placebo (Drug)
Ketamine low-dose
Loading: 0.5 mg/Kg Infusion: 5 mcg/kg/min
干预措施: Ketamine high-dose (Drug)
Ketamine high-dose
Loading: 1 mg/Kg Infusion: 10 mcg/kg/min
干预措施: Placebo (Drug)
Ketamine high-dose
Loading: 1 mg/Kg Infusion: 10 mcg/kg/min
干预措施: Ketamine low-dose (Drug)
结局指标
主要结局
Number of Participants With Opioid Consumption
时间窗: 1 day
Perioperative use of opioid consumption at Post Anesthesia Care Unit (PACU) Data obtained from patient charts
次要结局
- Participants With Nausea and Vomiting at PACU(1 day)
- Postoperative Pain(one day)
研究者
Roya Yumul, M.D.,PhD.
Residency program director, Department of anesthesiology
Cedars-Sinai Medical Center