Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery

Not Applicable

• Conditions: Postoperative Analgesia
• Interventions: Drug: Ketamine Hydrochloride; Drug: Normal saline

• Registration Number: NCT03344393
• Lead Sponsor: Assiut University

Brief Summary

.The aim of this study is to identify the analgesic effect of intraoperative ketamine intravenous infusion on patients undergoing intestinal surgery and its effect on salivary cortisol and alpha amylase levels as indicator of its effect.

Detailed Description

I- Group K (ketamine): 30 patients will receive intraoperative intravenous ketamine infusion.

II- Group C (control): 30 patients will receive intraoperative intravenous normal saline infusion.

Study Timeline

• Status Verified: 2017-11
• Study First Submitted: 2017-11-09
• Study First Submitted QC: 2017-11-13
• Last Update Submitted: 2017-11-13
• Study First Posted: 2017-11-17
• Last Update Posted: 2017-11-17
• Study Start: 2017-12-01
• Primary Completion: 2019-01-01
• Study Completion: 2019-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• • Patient's status ASA status-I and II.
• Patients age above 18 years old.
• Patients scheduled for intestinal surgery.

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Exclusion Criteria

• Patient refusal.
• Patients with known allergy to ketamine or morphine.
• Patients with significant hepatic dysfunction.
• Patients with severe renal disease.
• Significant Heart disease.
• Patients with chronic pain.
• Regular use analgesics, antidepressants or opioids in last 2 months.
• Any known convulsive disorder.
• Morbid obesity (BMI>35).
• Patients with autoimmune disease
• Patients on corticosteroid therapy
• Pregnancy.
• Breast feeding.
• Woman under hormonal treatment.
• Oral disease.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ketamine hydrochloride	Ketamine Hydrochloride	intravenous ketamine infusion in the intraoperative period
normal saline	Normal saline	intravenous normal saline infusion in the intraoperative period

Primary Outcome Measures

Name	Time	Method
morphine consumption	2 days postoperative	IV PCA

Secondary Outcome Measures

Name	Time	Method
cortisol level	2 days postoperative	salivary
alpha amylase level	2 days postoperative	salivary