A Pilot Study on Whey Protein Supplementation in Non Alcoholic Fatty Liver Disease
Not Applicable
Completed
- Conditions
- Non-alcoholic Fatty Liver DiseaseObesity
- Interventions
- Dietary Supplement: ProWHEY 94 CFM, SponserR
- Registration Number
- NCT00870077
- Lead Sponsor
- University of Lausanne
- Brief Summary
An increase in dietary protein intake has been shown to blunt the increase in intrahepatic fat induced by high fat feeding in healthy individuals. The purpose of this study is to determine if a protein supplementation decreases intrahepatic fat in obese patients with non-alcoholic fatty liver disease.
- Detailed Description
12 obese patients will be be treated with a dietary whey protein supplementation over 4 weeks. Their intrahepatic fat content, glucose tolerance, and body weight will be evaluated before and after 4 weeks of supplementation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- BMI higher than 35 kg/m2
- age 18-50 years
- sex male or female
- ASAT/ALAT > 1.8
Exclusion Criteria
- treatment with hypolemic or antidiabetic agents
- blood glucose > 7 mmol/l
- alcohol intake > 20g/day
- creatinin > 120 umol/l)
- contra-indications to Magnetic resonnance imaging
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 ProWHEY 94 CFM, SponserR -
- Primary Outcome Measures
Name Time Method intrahepatic fat before and after 4 weeks of whey protein supplementation
- Secondary Outcome Measures
Name Time Method glucose metabolism 4-hour oral glucose tolerance test with indirect calorimetry body weight and body fat before and after 4 weeks whey protein supplementation
Trial Locations
- Locations (1)
Centre d'investigations cliniques "cardiomet"/ CHUV
🇨ðŸ‡Lausanne, VD, Switzerland