Influence of increasing dietary protein on hepatic fat accumulation and postprandial metabolism.

Completed

• Conditions: Fatty liver; liver fat accumulation; 10018424; 10019654

• Registration Number: NL-OMON35839
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

healthy male subjects, 18 to 40 years old, body mass index (BMI) 18-25 kg/ m2, stable dietary habits and physical activity levels.

Exclusion Criteria

Unable or unwilling to comply with study procedures;
Not Caucasian
Unstable body weight (weight gain or loss > 3 kg in the past three months);
Moderate intense physical activity (exercise) for more than 4 hours/week
(Chronic) disease which might influence the study outcomes e.g. diabetes mellitus or any other endocrine disorder, active cardiovascular disease, hepatic disease, renal disease, cancer;
Family history of diabetes mellitus;
Use of medication, except incidental use of paracetamol;
Abuse of drugs;
Alcohol consumption of more than 14 glasses per week;
Participation in another biomedical study within 1 months prior to the first screening visit;
A contraindication to MRI scanning.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Hepatic fat accumulation measured with 1H- magnetic resonance spectroscopy<br /><br>(1H-MRS).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are postprandial lipid and glucose metabolism (meal<br /><br>challenge), adipose tissue gene expression and changes in gut microbiota.</p><br>