NCT00870077已完成不适用
Effect of a Whey Protein Supplementation on Intrahepatic Lipids in Obese Patients With Non-alcoholic Fatty Liver Disease
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- intrahepatic fat
研究概览
简要总结
An increase in dietary protein intake has been shown to blunt the increase in intrahepatic fat induced by high fat feeding in healthy individuals. The purpose of this study is to determine if a protein supplementation decreases intrahepatic fat in obese patients with non-alcoholic fatty liver disease.
详细描述
12 obese patients will be be treated with a dietary whey protein supplementation over 4 weeks. Their intrahepatic fat content, glucose tolerance, and body weight will be evaluated before and after 4 weeks of supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI higher than 35 kg/m2
- •age 18-50 years
- •sex male or female
- •ASAT/ALAT > 1.8
排除标准
- •treatment with hypolemic or antidiabetic agents
- •blood glucose > 7 mmol/l
- •alcohol intake > 20g/day
- •creatinin > 120 umol/l)
- •contra-indications to Magnetic resonnance imaging
研究组 & 干预措施
1
Experimental
干预措施: ProWHEY 94 CFM, SponserR (Dietary Supplement)
结局指标
主要结局
intrahepatic fat
时间窗: before and after 4 weeks of whey protein supplementation
次要结局
- glucose metabolism(4-hour oral glucose tolerance test with indirect calorimetry)
- body weight and body fat(before and after 4 weeks whey protein supplementation)
研究者
Luc Tappy, MD
professor of physiology
University of Lausanne
研究点 (1)
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