Evaluation of Perioperative Celecoxib for Hip Arthroscopy

Not Applicable

Completed

• Conditions: Hip Labral Tears
• Interventions: Drug: placebo; Drug: Celecoxib

• Registration Number: NCT02779166
• Lead Sponsor: Northwestern University

Brief Summary

Celecoxib is commonly used for perioperative pain control for certain orthopaedic procedures. It has been shown to be successful in assisting in pain control for knee arthroscopy. It has not previously been studied in hip arthroscopy. This is a double blinded randomized controlled trial to determine the efficacy of celecoxib in perioperative pain control for hip arthroscopy.

Detailed Description

This study examines the efficacy of perioperative dose of celecoxib in pain management after hip arthroscopy. Perioperative administration of celecoxib has been shown to improve pain control after knee arthroscopy, but this has not yet been studied in the hip. In this study, patients are randomized to receive either 400mg celecoxib or placebo 1 hour prior to undergoing hip arthroscopy surgery. Postoperatively, patients are monitored for pain on the VAS scale, narcotic use, and meeting discharge criteria. The study will enroll 100 patients. Patients are approached for informed consent on the day of surgery. Pain scores, narcotic use, and time to discharge in the celecoxib group are compared to the placebo group.

Study Timeline

• Study Start: 2012-08
• Primary Completion: 2016-01
• Study Completion: 2016-05
• Study First Submitted: 2016-05-13
• Study First Submitted QC: 2016-05-19
• Study First Posted: 2016-05-20
• Results First Submitted: 2017-02-13
• Results First Submitted QC: 2019-04-23
• Results First Posted: 2019-05-14
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-19
• Last Update Posted: 2019-09-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• All patients who are undergoing a hip arthroscopy procedure at Northwestern Memorial Hospital with Dr. Michael Terry.

Exclusion Criteria

• Pregnant women and any patient under the age of 18 years.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	placebo	Received placebo pill prior to surgery
Intervention	Celecoxib	Received 400mg celecoxib prior to surgery

Primary Outcome Measures

Name	Time	Method
Total Narcotic Consumption in the Post Anesthesia Care Unit (PACU)	duration of PACU stay,immediate post op period up to a maximum of 4 hours postoperatively	Monitored consumption of narcotic medications following surgery, measured in morphine equivalents
Visual Analog Score for Pain (VAS) in the Immediate Post Operative Period	Pre operative on day of surgery, immediately following OR close, 1 hr post operatively, 2 hrs post operatively	The pain VAS is a uni dimensional measure of pain intensity. It is a continuous scale comprised of a 0-10 pain rating. A score of 0 indicates no pain while a score of 10 would indicate extreme pain.
Time to Discharge Following Surgery	time from OR to discharge, up to a maximum of 6 hours postoperatively	Total time to discharge from OR close following surgery, measured in minutes