A study of the influence of amino acid composition intake on vascular function in healthy adults.

Not Applicable

• Conditions: Healthy volunteers

• Registration Number: JPRN-UMIN000022115
• Lead Sponsor: TTC CO., LTD.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2016-10-02
• Study Start: 2017-10-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

(1) Subjects who intake supplement and/or health foods, nutrition supplement, medicine, quasi-drug containing amino acid at advance examination. (2) Subjects who constantly eat watermelon at advance examination (e.g., more three times per week) (3) Subjects who constantly intake health foods and/or supplement or medicine, quasi-drug which may have vascular function improvement effect at advance examination (e.g., CoQ10, Nattokinase, Lutein, blueberry, Cassis, Vitamin E, Ginkgo leaf extract, melilot, Hesperidin as the polyphenols, Flavangenol, Pycnogenol) (4) Subjects having possibilities for emerging allergy related to the study. (5) Subjects who smoke at advance examination (including subjects who started smoking cessation within pre-three months at the time of advance examination) or hope smoking during study duration. (6) Subjects who ABI less than 0.90 at advance examination. (7) Subjects who have a history of serious disease (e.g., diabetes, liver disease, kidney disease, heart disease, cerebrovascular disease, malignant, anomaly of aminoacid metabolism, arrhythmia) (8) Subjects having a disease requiring treatment. (9) Subjects with a disease under treatment. (10) Subjects who are judged as unsuitable for the current study based on the results of clinical and physical preliminary examination. (11) Subjects who have a lifestyle affect the result of this study (ex. work on midnight shift) or subjects who are going to change to a lifestyle affect the result of this study (ex. work on midnight shift) (12) Subjects with a disease under treatment. (13) Subjects who are judged as unsuitable for the current study based on the results of lifestyle questionnaire. (14) Subjects who have participated in other clinical studies within the last one month prior to the current study or are planned to participate in other studies after obtaining informed consent for the current study. (15) Subjects judged as unsuitable for the current study by the investigator.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
baPWV(brachial-ankle pulse wave velocity)(0,12 weeks)

Secondary Outcome Measures

Name	Time	Method
1. FMD(flow-mediated dilatation) 2. ABI(ankle brachial index) 3. blood NOx(Nitrate+Nitrite) 4. blood amino acid concentration 5. ADMA(AsymmetricDimethylarginine) 6. SDPTG(second derivative of photoplethysmogram) 7. vascular age 8. VAS questionnaire