Targeted Abdominal CT in Conjunction With Lung Cancer Screening

Not Applicable

Not yet recruiting

• Conditions: Renal Cell Carcinoma (Kidney Cancer); Kidney Cancers; AAA - Abdominal Aortic Aneurysm; Renal Stones

• Registration Number: NCT07171190
• Lead Sponsor: University of Cambridge

Brief Summary

Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked. Those at higher risk of lung cancer are offered a lung scan.

This group also has a high risk of developing abdominal cancers, such as kidney cancer. A recent study explored whether it would be feasible to extend the lung scan to include the abdomen. Results showed most participants supported this addition, and the number of serious findings was similar to those detected in UK breast or bowel cancer screening programmes.

However, the abdominal scan was only offered on the day of the lung scan, giving little time for people to consider their decision. The process also added too much time to be practical for widespread implementation.

This new study will:

* Test whether mentioning the possible abdominal scan in the initial LCS invitation affects participation in LCS assessments.

* Test new processes to assess if the abdominal scan can be added to the lung scan with minimal extra time.

* Check if participants can be split between the lung scan only group and lung and abdominal scan group using an approach called 'cluster randomisation'. This will be important in case a bigger trial is needed.

* See whether the additional processes are acceptable

People aged 55-70 who are invited to the lung cancer screening will be eligible to take part in this study. Only those who are found to be at a high risk of lung cancer after their assessment, and therefore offered a lung scan, will be offered the abdominal scan, provided they have not had an abdominal scan in the previous 12 months or one booked in the next 3 months.

This study will take place in two existing lung cancer screening locations in Yorkshire.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-08-14
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-05
• Last Update Submitted: 2025-09-05
• Study First Posted: 2025-09-12
• Last Update Posted: 2025-09-12
• Study Start: 2025-10-01
• Primary Completion: 2027-10
• Study Completion: 2027-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 6272

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Attendance rate at the LCS phone call	12 weeks after invitation letter is sent	Attendance rate of the invitation intervention group to the LCS phone call is non-inferior to the attendance rate of the invitation control group and if so, whether it is superior.
Cluster randomisation assessment	At the point of LCS assessment, within 12 weeks of invitation	Successful cluster randomisation of participants into scan control and scan intervention groups as demonstrated by groups of similar size.
Impact of abdominal scan on throughput	Up to 6 months after invitation	Average number of participants scanned per standard LCS scanning day is no different when adding the ANCCT
Perceived impact of abdominal scan on throughput	Up to 6 months after invitation	Data from daily short questionnaire completed by scanning unit staff shows perceived impact of TACTICAL activities on normal LCS processes is no different when ANCCT is added for at least 80% of days
Incremental time taken for each TACTICAL1 task compared with the existing LCS processes.	Up to 6 months after invitation	The observed incremental time taken for each TACTICAL1 task compared with the existing LCS processes for a sub-sample of participants.
Over 75% of participants receiving abdominal scan are satisfied or very satisfied with their scanning unit experience	Up to 6 months after invitation	Over 75% of participants are satisfied or very satisfied with their scanning unit experience as demonstrated by a post-scan feedback questionnaire.

Secondary Outcome Measures

Name	Time	Method
Percentage of participants taking up offer of abdominal scan	Up to 6 months after invitation.	At least 80% of participants offered the ANCCT, accept the invitation and attend the scan