Cardioprotective Effects of Green Tea Versus Maté Intake

Phase 3

• Conditions: Dyslipidemia; Inflammation; Obesity
• Interventions: Dietary Supplement: Yerba Mate Tea; Dietary Supplement: Green tea; Dietary Supplement: Apple tea

• Registration Number: NCT00933647
• Lead Sponsor: Instituto de Cardiologia do Rio Grande do Sul

Brief Summary

The investigators aim to study the effects of green tea and maté consumption on lipid and inflammatory profiles in dyslipidemic and overweight subjects.

Detailed Description

Recommendations of lifestyle and dietary content changes are often made for primary prevention and improvement of many health conditions, including cardiovascular disease. For centuries, green tea (Camellia sinensis) has been linked to good health. Nowadays, it is considered a functional food because of its physiological benefits, mainly in terms of cardiovascular prevention. Green tea is considered one of the best sources of phenolic compounds, which possess antioxidant properties that may contribute to a reduction in the risk of cardiovascular disease. Lesser-known worldwide, but widely consumed in southern Latin America countries, yerba mate tea (Ilex paraguariensis) is also a good source of phenolic compounds. The antioxidant capacity of green tea has been extensively studied; however, few studies have reported that the antioxidant properties of maté tea is even greater than green tea. For this reason, the present study aims to compare the possible effects of the oral ingestion of maté and green tea on the lipid and inflammatory profiles in a southern Brazilian population.

Study Timeline

• Study Start: 2007-11
• Status Verified: 2009-07
• Study First Submitted: 2009-07-06
• Study First Submitted QC: 2009-07-06
• Study First Posted: 2009-07-07
• Last Update Submitted: 2009-07-10
• Last Update Posted: 2009-07-13
• Primary Completion: 2009-09
• Study Completion: 2009-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 195

Inclusion Criteria

• age 35-60 years
• non-treated dyslipidemia (TC > 200mg/dL and/or TG > 150 mg/dL and/or HDL-c < 40 mg/dL for men and 50mg /dL for women)
• BMI 25-35 Kg/m²

Exclusion Criteria

• use or indication for use of lipid-lowering agents and/or vitamin supplement
• non-steroids anti inflammatory use
• hormone replacement therapy
• contraceptive use
• pregnancy
• nursing
• unexplained weight loss (>2 Kg) 2 months before the study
• altered hepatic function
• those who do not sign the informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Yerba Mate Tea	Yerba Mate Tea	Subjects will drink 1000ml/day of yerba mate tea for 8 weeks.
Green Tea	Green tea	Subjects will drink 1000ml/day of green tea for 8 weeks.
Apple Tea	Apple tea	Subjects will drink 1000ml/day of apple tea for 8 weeks.

Primary Outcome Measures

Name	Time	Method
Improvement of lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and total cholesterol / HDL-cholesterol ratio) and inflammatory profiles (C- reactive protein and fibrinogen).	8 weeks

Secondary Outcome Measures

Name	Time	Method
Decreases in body weight, body mass index, body fat ratio, abdominal and waist circumferences and waist to hip ratio. Changes in glucose and insulin will also be evaluated.	8 weeks

Trial Locations

Locations (1)

Instituto de Cardiologia / Fundação Universitária de Cardiologia; 🇧🇷 Porto Alegre, RS, Brazil