ExploreCOVID – identification of optimal CT imaging biomarkers in combination with clinical markers and RT-PCR for diagnosis of COVID-19

• Conditions: COVID-19; U07.1; COVID-19, virus identified

• Registration Number: DRKS00023913
• Lead Sponsor: niversitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-21
• Study Completion: 2021-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 158

Inclusion Criteria

Study population:
• Patients with confirmed COVID-19 infection
• Patients with suspected COVID-19 associated respiratory syndrome with negative PCR testing
• Existing CT images of the chest
• Age = 18 years

Control cohort:
Healthy patients without symptoms and patients with lung diseases without suspicion of COVID-19

Exclusion Criteria

Age < 18 years

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Detection of imaging biomarkers for data-based diagnosis and treatment of COVID-19 patients

Secondary Outcome Measures

Name	Time	Method
2. Correlation of radiological findings with RT-PCR, clinical biomarkers and the course of the COVID-19 disease<br>3. Development of a clinical guideline and definition of clinically relevant imaging biomarkers for diagnosis, risk stratification and treatment response of COVID-19 patients<br>4. Development of an evidence-based guideline for the stratification and use of high-risk patients with the provision of an open access database.