Weight Loss and Exercise in Obese, Physically Limited, Older Women and Men
Phase 3
Completed
- Conditions
- Interventions
- Registration Number
- NCT00146107
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The purpose of this study is to determine the effect of weight loss and exercise on physical function, body fat and muscle mass, bone strength, and quality of life.
- Detailed Description
Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging and physical inactivity. The primary objectives of the proposed research are to evaluate the independent and combined effects of weig...
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 107
Inclusion Criteria
- Obese (BMI 30 or greater)
- Elderly (age 65 years or older)
- Frailty
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Exclusion Criteria
- Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results.
- Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 years, or current use of bone acting drugs.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Diet Weight loss 3 Exercise Exercise 4 Weight Loss and Exercise Weight loss and exercise
- Primary Outcome Measures
Name Time Method physical function one year
- Secondary Outcome Measures
Name Time Method body composition one year muscle protein synthesis one year quality of life one year cognition and mood one year metabolism one year bone mineral density 1 year
Trial Locations
- Locations (1)
Washington University School of Medicine
🇺🇸St Louis, Missouri, United States