Weight Loss and Exercise in Obese, Physically Limited, Older Women and Men

Registration Number
NCT00146107
Lead Sponsor
Washington University School of Medicine
Brief Summary

The purpose of this study is to determine the effect of weight loss and exercise on physical function, body fat and muscle mass, bone strength, and quality of life.

Detailed Description

Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging and physical inactivity. The primary objectives of the proposed research are to evaluate the independent and combined effects of weig...

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
107
Inclusion Criteria
  • Obese (BMI 30 or greater)
  • Elderly (age 65 years or older)
  • Frailty
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Exclusion Criteria
  • Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results.
  • Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 years, or current use of bone acting drugs.
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
2DietWeight loss
3ExerciseExercise
4Weight Loss and ExerciseWeight loss and exercise
Primary Outcome Measures
NameTimeMethod
physical functionone year
Secondary Outcome Measures
NameTimeMethod
body compositionone year
muscle protein synthesisone year
quality of lifeone year
cognition and moodone year
metabolismone year
bone mineral density1 year

Trial Locations

Locations (1)

Washington University School of Medicine

🇺🇸

St Louis, Missouri, United States

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