Weight Loss and Exercise in Frail Obese Elderly Subjects
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Washington University School of Medicine
- Enrollment
- 107
- Locations
- 1
- Primary Endpoint
- physical function
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to determine the effect of weight loss and exercise on physical function, body fat and muscle mass, bone strength, and quality of life.
Detailed Description
Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging and physical inactivity. The primary objectives of the proposed research are to evaluate the independent and combined effects of weight loss and exercise on physical function, body composition, bone and muscle metabolism, and quality of life in frail, obese elderly men and women. The central hypothesis is that in frail obese elderly subjects, weight loss will improve physical function and quality of life, while the addition of exercise will not only augment improvement in these outcomes, but also attenuate the adverse effects of weight loss on bone and muscle masses. To test this hypothesis, 110 elderly (65-85 years old) obese men and women (body mass index \[BMI\] \> 30 kg/m2) with physical frailty will be randomized to 4 treatment groups: 1) control, 2) 10% weight loss, 3) exercise training, and 4) 10% weight loss plus exercise training.
Investigators
Dennis T. Villareal
Associate Professor
Washington University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •Obese (BMI 30 or greater)
- •Elderly (age 65 years or older)
Exclusion Criteria
- •Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results.
- •Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 years, or current use of bone acting drugs.
Outcomes
Primary Outcomes
physical function
Time Frame: one year
Secondary Outcomes
- body composition(one year)
- muscle protein synthesis(one year)
- quality of life(one year)
- cognition and mood(one year)
- metabolism(one year)
- bone mineral density(1 year)