Effects of Exercise Interventions in Frail Middle-aged and Older Adults
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Change of Montreal Cognitive Assessment
研究概览
简要总结
This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.
详细描述
Exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. Various training options depending on various physical circumstances will be presented. However, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. In general, 3-6 months of frequent exercise can enhance physical and cognitive outcome.
The investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. This study designed to recruit 200 older adults with frailty. All the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. Outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged above 50 years old with frailty syndrome
排除标准
- •Acute illnesses, such as unstable cardiac dysrhythmia, sepsis, or unstable vital signs
- •Physical or Cognitive issues that make it difficult for the patients to participate in our program
结局指标
主要结局
Change of Montreal Cognitive Assessment
时间窗: Up to 6 months
Test cognition including memory, attention, and language, range from 0-30, higher values represent a greater outcome
Change of Geriatric Depression Scale
时间窗: Up to 6 months
Test depression status, , range from 0-15, higher values represent a worse outcome
Change of Lawton Instrumental Activities of Daily Living (IADL) Scale
时间窗: Up to 6 months
To assesses a person's ability to perform tasks such as using a telephone, doing laundry, and handling finances.y. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent)
Change of Barthel index
时间窗: Up to 6 months
Test function of activities of daily living, range from 0-100, higher values represent a greater outcome.
次要结局
- Change of Digit symbol substitution test(Up to 6 months)
- Change of Six-minute Walking Test(Up to 6 months)
- Change of Timed Get-up-and-go Test(Up to 6 months)
- Change of Memory span test(Up to 6 months)
- Change of Mini-mental state examination(Up to 6 months)
- Change of Color Trails Test(Up to 6 months)