Effects of Exercise Interventions in Frail Middle-aged and Older Adults
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- Taipei Veterans General Hospital, Taiwan
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Change of Montreal Cognitive Assessment
- Last Updated
- 4 years ago
Overview
Brief Summary
This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.
Detailed Description
Exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. Various training options depending on various physical circumstances will be presented. However, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. In general, 3-6 months of frequent exercise can enhance physical and cognitive outcome. The investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. This study designed to recruit 200 older adults with frailty. All the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. Outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients aged above 50 years old with frailty syndrome
Exclusion Criteria
- •Acute illnesses, such as unstable cardiac dysrhythmia, sepsis, or unstable vital signs
- •Physical or Cognitive issues that make it difficult for the patients to participate in our program
Outcomes
Primary Outcomes
Change of Montreal Cognitive Assessment
Time Frame: Up to 6 months
Test cognition including memory, attention, and language, range from 0-30, higher values represent a greater outcome
Change of Geriatric Depression Scale
Time Frame: Up to 6 months
Test depression status, , range from 0-15, higher values represent a worse outcome
Change of Lawton Instrumental Activities of Daily Living (IADL) Scale
Time Frame: Up to 6 months
To assesses a person's ability to perform tasks such as using a telephone, doing laundry, and handling finances.y. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent)
Change of Barthel index
Time Frame: Up to 6 months
Test function of activities of daily living, range from 0-100, higher values represent a greater outcome.
Secondary Outcomes
- Change of Digit symbol substitution test(Up to 6 months)
- Change of Six-minute Walking Test(Up to 6 months)
- Change of Timed Get-up-and-go Test(Up to 6 months)
- Change of Memory span test(Up to 6 months)
- Change of Mini-mental state examination(Up to 6 months)
- Change of Color Trails Test(Up to 6 months)