Study of the prevalence of aspirin sensitivity in patients with chronic rhinosinusitis and nasal polyposis coming to allergy department of Rasool-e-Akram hospital according to response to standard treatment after three months.
Phase 2
- Conditions
- chronic rhinosinusitis with nasal polyposis.Other polyp of sinus Polyp of sinus: accessory ethmoidal maxillary sphenoidal
- Registration Number
- IRCT2015061322531N1
- Lead Sponsor
- Vce chancellor for research of Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
age 18-65 years old; presence of symptoms of chronic rhinosinusitis with nasal polyps which is documented on CT scan.
Exclusion criteria: existence of any serious underlying disease such as bleedin tendency, gastrointestinal, rheumatologic, malignancy, cardiac, renal, hepatic, psychological; history of IgE mediated reactions to aspirin or nonsteroidal anti inflammatory drugs; first second expiratory volume of more than 70 percent of predicted before aspirin challenge test; pregnancy; breast feeding; use of topical and systemic beta blockers; use of warfarin and warfarin derivates; mastocytosis; patients with poor cooperation and poor adherence.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of symptoms of chronic rhinosinusitis with nasal polyposis. Timepoint: after 3 months. Method of measurement: Sino Nasal Outcome Test (SNOT) questionnaire.
- Secondary Outcome Measures
Name Time Method Complications of conventional treatment including epistaxis, nasal burning sensation, nasal septal perforation, feeling sleepy. Timepoint: before intervention, three months after intervention. Method of measurement: history taking.