aspirin hypersensitivity

Not Applicable

Conditions: asal polyp.
Nasal polyp

Registration Number: IRCT201408191138N12

Lead Sponsor: Guilan University of Medical Sciences,Vice Chancellor for Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 96

Inclusion Criteria

All patients with nasal polyps that including male and female and in range of 18-60 years old who referred to ENT service in Rasht, Amiralmomenin hospital and diagnosis of nasal polyps is definite for them by endoscopy or CTs if don't have contraindications for oral aspirin challenge test inclusion to our study.
Those with contraindications for oral aspirin challenge test were left out of the study :
1-a history of very severe anaphylactic reaction,
2-severe disease of the heart, digestive tract, liver and kidney,
3- infection of respiratory tract within 4weeks prior to the challenges,
4- pregnancy,
5- current treatment with beta receptor blocker.
Control group is healthy people that don't have nasal polyps and contraindications for oral aspirin challenge test.
Exclusion criteria:If the result of test is positive.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
asoocular symptoms alone. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection.;Nasoocular symptoms and a 15% or greater decline in FEV(classic reaction). Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.;Lower respiratory reaction only (FEV1 declines by >20%). Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.;Laryngospasm with or without any of the first 3 reactions. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.;Systemic reactions: hives, flushing, gastric pain, hypotension. Timepoint: every 1 hour to 3 h after each dose of aspirin. Method of measurement: clinical inspection and physical exam.

Secondary Outcome Measures