Cognitive Flexibility and Creativity in People with Parkinson*s: A Pilot Study Exploring the Influence of Dopaminergic Regulation on Cognitive Flexibility and Creativity, with an Emphasis on Visual Art

Conditions: Parkinson's disease
10028037

Registration Number: NL-OMON56761

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

- 18 years of age or older
- diagnosed with idiopathic Parkinson*s disease
- willingness to participate in the intervention program and attend all
scheduled test sessions
- young-onset Parkinson*s, i.e., symptoms appeared between the age of 18-40
years of age

Exclusion Criteria

- received deep brain stimulation (brain surgery)
- severe co-morbidities or other additional neurodegenerative diseases or
disorders (except PD/medication related mood disorders)
- legally incompetent adults who are unable to provide informed consent or
manage their own affairs.
- requirement for full-time nursing care.
- absence of written informed consent from the participant.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome<br /><br>1. Applicability and Feasibility: Given the potential symptom-related<br /><br>confounders in PD, such as severe motor issues (tremor, dystonia) and impulsive<br /><br>rejection of conducting tasks, it is critical to determine whether the tasks<br /><br>and the entire battery are practical and feasible.<br /><br>2. Face Validity Assessment: This pilot will involve subjective evaluation by a<br /><br>research team (including psychologists) through observing participants during<br /><br>the tasks to assess if the tests cover the concept they purport to measure,<br /><br>thus gauging the face validity.<br /><br>3. External Validity Assessment: We intend to visit people in their homes and<br /><br>interview both participants and caregivers, considering participants* daily<br /><br>life circumstances, issues, and behaviour to ensure the external validity<br /><br>(considering widening the results to their homes) of our findings.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objective is to get first insights into potential relationships<br /><br>of the explored outcomes of the test battery. Within this small cohort,<br /><br>investigations into the relationships between PD, dopamine, creativity,<br /><br>cognitive flexibility, and PD/dopaminergic-induced mood and behavioural changes<br /><br>are considered explorative research.</p><br>