Impact of a non-invasive positive pressure ventilation protocol in comparation with non-protocolised strategy of ventilation in children hospitalised with acute respiratory failure

Not Applicable

Completed

• Conditions: Acute lower respiratory infection; Respiratory

• Registration Number: ISRCTN77954355
• Lead Sponsor: Hospital Josefina Martinez

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-10-31
• Study Start: 2017-01-06
• Last Update Posted: 3 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Hospitalized in Hospital Josefin Martinez
2. Aged between 3 months and 2 years
3. Diagnosis of acute lower respiratory infection
4. Need of NIPPV, according to Modified Wood Scale (MWS) with score = 4 points

Exclusion Criteria

1. Prior use of NIV
2. History of respiratory comorbidities

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Time of connection to Non Invasive Positive Pressure ventilation (NIPPV) measured in hours by a record table (designed for the purpose of this study) at baseline, and follow up until withdrawal occurs<br> 2. Duration of hospitalization measured in hours by a record table (designed for the purpose of this study) at baseline, and follow up until discharge occurs<br> 3. Use of additional oxygen after withdrawal of NIPPV measured in hours by a record table (designed for the purpose of this study) at baseline, and follow up until discontinuation<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Severity of respiratory symptoms is measured using the Modified Wood Scale Score (MWS) at baseline and 1 hour after NIPPV start<br> 2. Severity of respiratory symptoms in the protocol group is measured using the Modified Wood Scale Score (MWS) at baseline and 1, 24 hours after NIPPV start and at 4 hours after change of mode to CPAP prior to disconnection<br> 3. Oxygenation in the protocol group after connection to NIPPV measured using the SAFI index at 1 and 24 hours after NIPPV start<br> 4. Proportion of intubation (Need of Invasive ventilator support) measured frequency and % at the end of follow up<br>