PACTR202112653971335
Completed
Phase 3
Impact of pressure targeted modes of ventilation on diaphragmatic function as assessed using ultrasonography in critically ill patients with cerebral insult
Not provided0 sites60 target enrollmentDecember 6, 2021
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Respiratory
- Sponsor
- Not provided
- Enrollment
- 60
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients age \= 21 years.
- •Both genders.
- •Mechanically ventilated patients due to primary cerebral insult (ischemic or hemorrhagic or embolic incident) or secondary to traumatic brain injury in ER or OR.
- •Eligible for proposed pressure targeted modes of mechanical ventilation.
- •Hemodynamically stable patients or with minimal doses of vasopressors or inotropes.
- •Minimal doses of sedation if needed.
Exclusion Criteria
- •Refusal of the legal guardians to the intervention or participation of the patient in the study.
- •Use of Neuromuscular blockers.
- •Patient \< 21 years old.
- •Diaphragmatic dysfunction on ICU admission.
- •History of Diaphragmatic palsy or Diaphragmatic hernia.
- •History of brainstem injury or cervical spine injury or neuromuscular disease.
- •Severe Hemodynamically unstable patients.
- •Presence of ascites or colonic distention or any mechanical factor in the chest or abdomen interfering with diaphragmatic mobility.
- •Presence of chest deformities or pneumothorax or pneumomediastinum or pleurodesis or moderate to severe pleural effusion or surgical emphysema in the chest.
- •Rhabdomyolsis.
Outcomes
Primary Outcomes
Not specified
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